Irino O, Saitoh K, Bando K, Uchida M, Honda H
Nihon Yakurigaku Zasshi. 1987 Apr;89(4):197-202. doi: 10.1254/fpj.89.197.
Effects of ifenprodil tartrate on whole blood filtrability ex vivo in rats was investigated by a standard technique for measuring whole blood filtration time passed through a filter (5 micron). Ifenprodil tartrate was observed to reduce the filtration time dose-responsively. This effect was especially evident at 20 mg/kg (P less than 0.05). On the other hand, no effect on the hematocrit value, plasma concentration of fibrinogen, erythrocyte count or mean cellular volume of erythrocytes was observed. These results indicated the increasing effects ex vivo of ifenprodil tartrate on erythrocyte deformability. The ex vivo effects on erythrocyte deformability was manifested without changing the ATP contents, ATP/ADP ratio or adenylate energy charge in erythrocytes; and a phenothiazine-like amelioration in the shape of crenated erythrocytes was observed. These results suggested that the effect of ifenprodil tartrate on erythrocyte deformability ex vivo might be due to direct action on the erythrocyte membrane. At 0.3 mg/kg, i.v., ifenprodil tartrate significantly (P less than 0.05) increased the blood flow in the hypothalamus of conscious rats. Thus, it was indicated that ifenprodil tartrate, which increases the erythrocyte deformability and the cerebral blood flow, is useful for the therapeutic treatment of cerebrovascular accidents.
采用一种通过5微米滤器测量全血过滤时间的标准技术，研究了酒石酸艾芬地尔对大鼠离体全血过滤性的影响。观察到酒石酸艾芬地尔可剂量依赖性地缩短过滤时间。在20mg/kg时这种作用尤为明显（P<0.05）。另一方面，未观察到对血细胞比容值、血浆纤维蛋白原浓度、红细胞计数或红细胞平均细胞体积有影响。这些结果表明酒石酸艾芬地尔在离体条件下对红细胞变形性有增强作用。对红细胞变形性的离体作用在不改变红细胞内ATP含量、ATP/ADP比值或腺苷酸能荷的情况下表现出来；并且观察到对皱缩红细胞形状有类似吩噻嗪的改善作用。这些结果提示酒石酸艾芬地尔在离体条件下对红细胞变形性的作用可能是由于对红细胞膜的直接作用。静脉注射0.3mg/kg酒石酸艾芬地尔可显著（P<0.05）增加清醒大鼠下丘脑的血流量。因此，表明增加红细胞变形性和脑血流量的酒石酸艾芬地尔对脑血管意外的治疗是有用的。
