Laboratory of Human Genetics, School of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
Fuji-no-Kuni Center for Future Education, Center of Community (COC) for Healthy Longevity, Promoting Physical, Mental and Community Health, University of Shizuoka, Shizuoka, Japan.
Lifestyle Genom. 2022;15(4):124-130. doi: 10.1159/000525859. Epub 2022 Sep 13.
In mammals, circadian rhythms regulate many behavioral and physiological processes. Genetic and epidemiological studies have shown that dysregulation of the circadian rhythm induces chronic metabolic diseases, such as obesity, diabetes, and dyslipidemia. We aimed to know the interactions of genetic variations of seven core circadian clock genes with lifestyle factors on the determination of metabolic parameters.
We have analyzed the impacts of genotype of seven core circadian clock genes (i.e., CLOCK, BMAL1, PER1, PER2, PER3, CRY1, and CRY2) and lifestyle factors (i.e., physical activity and sleep duration) in 575 Japanese males on the determination of metabolic parameters (i.e., body mass index [BMI], serum glucose, glycated hemoglobin [HbA1c], low-density lipoprotein cholesterol [LDL-C], and high-density lipoprotein cholesterol [HDL-C] levels).
We have detected the associations between genotypes of PER3 and serum HbA1c level and genotypes of CRY1 and serum LDL-C level. Additionally, the interactions of the genotypes of PER1 and PER3 with physical activity for determining BMI, the genotypes of CLOCK with physical activity for determining serum HbA1c levels were observed. Furthermore, for determining serum HDL-C levels, the interactions of the genotypes of CRY2 with physical activity or sleep duration were observed.
DISCUSSION/CONCLUSION: Our findings indicate that the interactions of genotypes for core circadian clock genes and lifestyle factors (i.e., physical activity and sleep duration) are important for determining metabolic parameters.
在哺乳动物中，昼夜节律调节许多行为和生理过程。遗传和流行病学研究表明，昼夜节律失调会导致慢性代谢疾病，如肥胖、糖尿病和血脂异常。我们旨在了解七个核心生物钟基因的遗传变异与生活方式因素相互作用对代谢参数的影响。
我们分析了七个核心生物钟基因（即 CLOCK、BMAL1、PER1、PER2、PER3、CRY1 和 CRY2）的基因型和生活方式因素（即体力活动和睡眠时间）对 575 名日本男性代谢参数（即体重指数[BMI]、血清葡萄糖、糖化血红蛋白[HbA1c]、低密度脂蛋白胆固醇[LDL-C]和高密度脂蛋白胆固醇[HDL-C]水平）的影响。
我们检测到 PER3 基因型与血清 HbA1c 水平和 CRY1 基因型与血清 LDL-C 水平之间的关联。此外，还观察到 PER1 和 PER3 基因型与体力活动对 BMI 的影响，CLOCK 基因型与体力活动对血清 HbA1c 水平的影响存在交互作用。此外，还观察到 CRY2 基因型与体力活动或睡眠时间对血清 HDL-C 水平的影响存在交互作用。
讨论/结论：我们的研究结果表明，核心生物钟基因的基因型与生活方式因素（即体力活动和睡眠时间）之间的相互作用对确定代谢参数很重要。
