Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
Department of Neuroscience, Box Hill Hospital, Eastern Health, Melbourne, Victoria, Australia.
Intern Med J. 2022 Sep;52(9):1633-1637. doi: 10.1111/imj.15903.
Acute ischaemic strokes occur despite the use of direct oral anticoagulants (DOACs). A retrospective review was conducted at a high-volume primary stroke centre over a 3-year period to assess the acute management of stroke presentations in patients prescribed DOACs. During the time period of the study, 103 of 195 anticoagulated stroke patients presented within the timeframe for thrombolysis and only 15 patients had DOAC plasma level assays performed. Of these 103, 5 received thrombolysis; however, DOAC level was not a factor in these cases.
尽管使用了直接口服抗凝剂(DOACs),仍会发生急性缺血性中风。在一家高容量的初级中风中心进行了为期 3 年的回顾性研究,以评估在使用 DOAC 处方的患者中风发作的急性管理。在研究期间,195 名接受抗凝治疗的中风患者中有 103 名在溶栓时间窗内出现,只有 15 名患者进行了 DOAC 血浆水平检测。在这 103 名患者中,有 5 名接受了溶栓治疗;然而,在这些情况下,DOAC 水平并不是一个因素。