高压氧治疗对放射性皮肤弹性的影响。
Effect of hyperbaric oxygen treatment on skin elasticity in irradiated patients.
机构信息
Department of Surgery/Hyperbaric Medicine, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Corresponding author: Karan Pandey, Department of Hyperbaric Medicine, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands,
出版信息
Diving Hyperb Med. 2022 Sep 30;52(3):208-212. doi: 10.28920/dhm52.3.208-212.
BACKGROUND
Hyperbaric oxygen treatment (HBOT) is often used in an attempt to reverse/treat late radiation-induced tissue fibrosis (LRITF). This study aimed to quantify the effects on skin elasticity.
METHODS
Skin retraction time was used as a marker of skin elasticity in 13 irradiated breast cancer patients. The measurements were carried out on the affected side as well as the unaffected/healthy side at a mirrored location. Readings were taken at the start and end of HBOT (mean 43 sessions, 80 min at 243 kPa).
RESULTS
Patient age ranged from 39-70 years. All patients underwent surgical lumpectomy and radiotherapy prior to undergoing HBOT. The mean time between radiotherapy and HBOT was 70 months. Seven of the 13 patients underwent chemotherapy. Mean irradiated skin retraction time improved from 417 (SD 158) pre-HBOT to 171 (24) msec post-HBOT (P < 0.001). Mean pre-HBOT retraction time in the non-irradiated skin was 143 (20) msec and did not change.
CONCLUSIONS
This promising pilot study that suggests that HBOT may improve skin elasticity in patients with LRITF.
背景
高压氧治疗（HBOT）常被用于逆转/治疗晚期放射性组织纤维化（LRITF）。本研究旨在定量评估其对皮肤弹性的影响。
方法
本研究纳入 13 名接受过放疗的乳腺癌患者，以皮肤回缩时间作为皮肤弹性的标志物。在受影响的一侧以及镜像位置的未受影响/健康侧进行测量。在 HBOT 开始和结束时（平均 43 次，243 kPa 下 80 分钟）进行读数。
结果
患者年龄为 39-70 岁。所有患者均在接受 HBOT 治疗前接受了手术乳房切除术和放疗。放疗与 HBOT 之间的平均时间为 70 个月。13 名患者中有 7 名接受了化疗。HBOT 前的皮肤回缩时间均值从 417（SD 158）msec 改善到 HBOT 后 171（24）msec（P < 0.001）。HBOT 前非照射皮肤的回缩时间均值为 143（20）msec，无明显变化。
结论
本研究为一项有前景的初步研究，表明 HBOT 可能改善 LRITF 患者的皮肤弹性。
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