Medirex Group Academy n.p.o., Novozamocka 67, Nitra, Slovakia.
Faculty of Medicine, Department of Clinical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava, Sasinkova 4, Bratislava, Slovakia.
Curr Diabetes Rev. 2023;19(9):e130922208761. doi: 10.2174/1573399819666220913113146.
Currently, when the world is fighting against the rapidly spreading pandemic of COVID-19, the silent epidemic of diabetes should not be set aside. In comparison, while COVID- 19 led to about 6 million deaths in 2021, diabetes caused 6.7 million deaths in the same year. Diabetes mellitus is a serious risk factor for worse outcomes in COVID-19 patients. Moreover, it seems that there is a bidirectional relationship between pre-existing diabetes pandemic and the rapidly spreading COVID-19 pandemic. In this article, we summarize mechanisms by which SARS-CoV-2 infects the host cell and discuss the bidirectional relationship between diabetes and COVID-19. We also focus on clinical variables in which diabetic patients differ from non-diabetic patients and which could have promising predictive value for the course and outcome of diabetic COVID-19 patients' therapy management.
目前，当全世界都在与迅速蔓延的 COVID-19 大流行作斗争时，糖尿病这一无声的流行疾病不应被忽视。相比之下，虽然 COVID-19 在 2021 年导致约 600 万人死亡，但糖尿病在同年导致 670 万人死亡。糖尿病是 COVID-19 患者病情恶化的严重危险因素。此外，似乎糖尿病大流行和迅速蔓延的 COVID-19 大流行之间存在双向关系。在本文中，我们总结了 SARS-CoV-2 感染宿主细胞的机制，并讨论了糖尿病和 COVID-19 之间的双向关系。我们还重点关注了糖尿病患者与非糖尿病患者存在差异的临床变量，这些变量可能对糖尿病 COVID-19 患者治疗管理的病程和结果具有有前途的预测价值。
