Student Research Committee, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2021;1321:53-68. doi: 10.1007/978-3-030-59261-5_5.
Following the outbreaks of SARS-CoV in 2002 and MERS-CoV in 2012, the COVID-19 pandemic caused by the SARS-CoV-2 virus has become an increasing threat to human health around the world. Numerous studies have shown that SARS-CoV-2 appears similar to the SARS-CoV as it uses angiotensin converting enzyme 2 (ACE2) as a receptor to gain entry into cells. The main aims of this scoping review were to identify the primary hosts of coronaviruses, the relationship between the receptor binding domain of coronaviruses and ACE2, the organ specificity of ACE2 expression compared with clinical manifestations of the disease, and to determine if this information can be used in the development of novel treatment approaches for the COVID-19 pandemic.
继 2002 年 SARS-CoV 和 2012 年 MERS-CoV 爆发后，由 SARS-CoV-2 病毒引起的 COVID-19 大流行已成为全球人类健康的日益威胁。大量研究表明，SARS-CoV-2 与 SARS-CoV 相似，因为它使用血管紧张素转换酶 2（ACE2）作为受体进入细胞。本范围综述的主要目的是确定冠状病毒的主要宿主，冠状病毒的受体结合域与 ACE2 的关系，ACE2 表达与疾病临床表现的器官特异性，并确定这些信息是否可用于开发针对 COVID-19 大流行的新型治疗方法。
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