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接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者血液学指标与TIMI血流的相关性

The Association Between Hematologic Indices with TIMI Flow in STEMI Patients who Undergo Primary Percutaneous Coronary Intervention.

作者信息

Parsa Saeed Alipour, Nourian Saeed, Safi Morteza, Namazi Mohammad Hasan, Saadat Habib, Vakili Hossein, Eslami Vahid, Salehi Ayoub, Kiaee Farshid Heidarpour, Sohrabifar Nasim, Khaheshi Isa

机构信息

Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Cardiovasc Hematol Disord Drug Targets. 2022;22(3):162-167. doi: 10.2174/1871529X22666220913122046.

Abstract

BACKGROUND

The Primary Percutaneous Coronary Intervention (PPCI) is the preferred therapeutic strategy for patients who experienced ST-Elevation Myocardial Infarction (STEMI).

OBJECTIVE

We aimed to evaluate the association of hematological indices, including hemoglobin level, platelets, White Blood Cells (WBCs) count, and MPV before PPCI with the TIMI grade flow after PPCI.

METHODS

STEMI patients who experienced PPCI were included in the present retrospective crosssectional study. Then participants were divided into three groups based on their post-procedural TIMI flow grades. Demographic data and hematologic indices of patients before PPCI were collected and their association with the TIMI grade flow after PPCI was evaluated. To compare the quantitative and qualitative variables, chi-square and t-tests were performed, respectively.

RESULTS

We found that elevated levels of hemoglobin and decreased levels of MPV had a significant association with an advanced grade of TIMI flow. Interestingly, in the normal range, there was a significant association between higher platelet count and TIMI-flow grade 1. Besides, TIMI flow grades 2 and 3 had a significant association with low and moderate platelets count, respectively.

CONCLUSION

In conclusion, evaluating MPV, platelets, and hemoglobin levels before PPCI as easy and accessible parameters may be able to identify high-risk STEMI patients undergoing PPCI.

摘要

背景

直接经皮冠状动脉介入治疗(PPCI)是ST段抬高型心肌梗死(STEMI)患者的首选治疗策略。

目的

我们旨在评估PPCI术前血液学指标,包括血红蛋白水平、血小板、白细胞(WBC)计数和平均血小板体积(MPV)与PPCI术后心肌梗死溶栓治疗(TIMI)血流分级之间的关联。

方法

本回顾性横断面研究纳入了接受PPCI的STEMI患者。然后根据术后TIMI血流分级将参与者分为三组。收集患者PPCI术前的人口统计学数据和血液学指标,并评估它们与PPCI术后TIMI血流分级的关联。为比较定量和定性变量,分别进行了卡方检验和t检验。

结果

我们发现血红蛋白水平升高和MPV水平降低与更高的TIMI血流分级显著相关。有趣的是,在正常范围内,较高的血小板计数与TIMI血流1级之间存在显著关联。此外,TIMI血流2级和3级分别与低和中等血小板计数显著相关。

结论

总之,将PPCI术前的MPV、血小板和血红蛋白水平作为简单易获取的参数进行评估,可能能够识别接受PPCI的高危STEMI患者。

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