Goetze Jens P, Bartels Emil D, Shalmi Theodor W, Andraud-Dang Lilian, Rehfeld Jens F
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Biology (Basel). 2022 Jun 27;11(7):971. doi: 10.3390/biology11070971.
Production and release of natriuretic peptides and other vasoactive peptides are tightly regulated in mammalian physiology and involved in cardiovascular homeostasis. As endocrine cells, the cardiac myocytes seem to possess almost all known chemical necessities for translation, post-translational modifications, and complex peptide proteolysis. In several ways, intracellular granules in the cells contain not only peptides destined for secretion but also important granin molecules involved in maintaining a regulated secretory pathway. In this review, we will highlight the biochemical phenotype of the endocrine heart recapitulating that the cardiac myocytes are capable endocrine cells. Understanding the basal biochemistry of the endocrine heart in producing and secreting peptides to circulation could lead to new discoveries concerning known peptide products as well as hitherto unidentified cardiac peptide products. In perspective, studies on natriuretic peptides in the heart have shown that the post-translational phase of gene expression is not only relevant for human physiology but may prove implicated also in the development and, perhaps one day, cure of human cardiovascular disease.
利钠肽和其他血管活性肽的产生与释放在哺乳动物生理学中受到严格调控，并参与心血管稳态。作为内分泌细胞，心肌细胞似乎具备翻译、翻译后修饰以及复杂肽类蛋白水解所需的几乎所有已知化学物质。在多个方面，细胞内的颗粒不仅含有注定要分泌的肽，还含有参与维持调控分泌途径的重要颗粒蛋白分子。在本综述中，我们将着重介绍内分泌心脏的生化表型，概括心肌细胞是有功能的内分泌细胞这一观点。了解内分泌心脏在产生和分泌肽至循环系统方面的基础生物化学，可能会带来有关已知肽产物以及迄今未鉴定的心脏肽产物的新发现。从长远来看，对心脏利钠肽的研究表明，基因表达的翻译后阶段不仅与人类生理学相关，或许有一天还可能被证明与人类心血管疾病的发生及治疗有关。
