Nakagawa Yasuaki, Nishikimi Toshio
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Department of Medicine, Wakakusa Tatsuma Rehabilitation Hospital, 1580 Ooaza Tatsuma, Daito City 574-0012, Japan.
Biology (Basel). 2022 Jun 29;11(7):986. doi: 10.3390/biology11070986.
The natriuretic peptide family consists of three biologically active peptides: ANP, BNP, and CNP. CNP is more widely expressed than the other two peptides, with significant levels in the central nervous system, osteochondral system, and vascular system. The receptor that is mainly targeted by CNP is GC-B, which differs from GC-A, the receptor targeted by ANP and BNP. Consequently, the actions of CNP differ somewhat from those of ANP and BNP. CNP knockout leads to severe dwarfism, and there has been important research into the role of CNP in the osteochondral system. As a result, a CNP analog is now available for clinical use in patients with achondroplasia. In the cardiovascular system, CNP and its downstream signaling are involved in the regulatory mechanisms underlying myocardial remodeling, cardiac function, vascular tone, angiogenesis, and fibrosis, among others. This review focuses on the roles of CNP in the cardiovascular system and considers its potential for clinical application in the treatment of cardiovascular diseases.
心钠肽（ANP）、脑钠肽（BNP）和C型利钠肽（CNP）。CNP的表达比其他两种肽更广泛，在中枢神经系统、骨软骨系统和血管系统中含量显著。CNP主要作用的受体是GC-B，它不同于ANP和BNP作用的受体GC-A。因此，CNP的作用与ANP和BNP的作用有所不同。CNP基因敲除会导致严重侏儒症，并且对CNP在骨软骨系统中的作用已有重要研究。结果，一种CNP类似物现已可用于软骨发育不全患者的临床治疗。在心血管系统中，CNP及其下游信号传导参与心肌重塑、心脏功能、血管张力、血管生成和纤维化等潜在的调节机制。本综述重点关注CNP在心血管系统中的作用，并探讨其在心血管疾病治疗中的临床应用潜力。
