Hebert Adelaide Ann
UTHealth McGovern Medical School, Houston, TX, USA.
Clin Cosmet Investig Dermatol. 2022 Sep 7;15:1797-1803. doi: 10.2147/CCID.S364934. eCollection 2022.
Atopic and contact dermatitis have been attributed to skin barrier abnormalities, immune system dysfunction and inflammation leading to pruritus. As these factors may involve oxidative stress, emollient devices containing antioxidants furfuryl palmitate and tocopherol may help reduce itching and inflammation. In this study, a post-marketing questionnaire was carried out of 40 users of a novel emollient device containing furfuryl palmitate and tocopherol (Relizema™ cream), who purchased it from a pharmacy or health-care professional to ascertain the emollient device's action on itching, flushing and moisturizing.
The post-marketing questionnaire, administered by trained pharmacy and health-care staff, collected data on age; diagnosis; number of times per day and for how many days the emollient device was applied; whether the product helped alleviate itching and flushing, and in what time frame if so; and how their skin felt after using the emollient.
Most patients had atopic dermatitis (n = 25) or irritant contact dermatitis (n = 10); most were aged ≥19 years (n = 20) or between 3 and 12 years (n = 12). Most used the emollient device twice a day (n = 26) or more (n = 11) with 27 using it for ≤30 days. Patients predominantly reported that the emollient device "significantly improved" itching (n = 34) and flushing (n = 31) with a response being noted within 1 day (n = 17) or 1 week (n = 22). All users felt the product "protected and moisturized" their skin, the product texture was "pleasant" to "excellent" and the "non-fragrance" smell was "acceptable" to "excellent".
Use of a novel emollient device containing ingredients aimed at managing atopic or contact dermatitis, including furfuryl palmitate and tocopherol, led to rapid improvements in itching and flushing. The emollient device was acceptable to the users.
特应性皮炎和接触性皮炎被认为与皮肤屏障异常、免疫系统功能障碍及炎症导致瘙痒有关。由于这些因素可能涉及氧化应激，含有抗氧化剂棕榈酸糠酯和生育酚的润肤装置可能有助于减轻瘙痒和炎症。在本研究中，对40名从药店或医疗保健专业人员处购买了含有棕榈酸糠酯和生育酚的新型润肤装置（Relizema™乳膏）的使用者进行了上市后问卷调查，以确定该润肤装置对瘙痒、脸红和保湿的作用。
由经过培训的药店和医护人员进行的上市后问卷调查收集了以下数据：年龄；诊断结果；每天使用润肤装置的次数及使用天数；该产品是否有助于缓解瘙痒和脸红，若有帮助，在多长时间内起效；以及使用润肤产品后皮肤的感觉。
大多数患者患有特应性皮炎（n = 25）或刺激性接触性皮炎（n = 10）；大多数患者年龄≥19岁（n = 20）或在3至12岁之间（n = 12）。大多数患者每天使用润肤装置两次（n = 26）或更多次（n = 11），其中27人使用时间≤30天。患者主要报告称，该润肤装置“显著改善”了瘙痒（n = 34）和脸红（n = 31），在1天内（n = 17）或1周内（n = 22）有效果。所有使用者都感觉该产品“保护并滋润”了他们的皮肤，产品质地从“宜人”到“极佳”，“无香料”气味从“可接受”到“极佳”。
使用含有旨在治疗特应性皮炎或接触性皮炎成分（包括棕榈酸糠酯和生育酚）的新型润肤装置，可迅速改善瘙痒和脸红症状。该润肤装置为使用者所接受。
