Schreiber A G, Maderazo E G
Arch Pathol Lab Med. 1978 Oct;102(10):534-7.
Leukocytic functions were studied in a patient with malakoplakia that involved the urinary tract and retroperitoneum in whom recalcitrant infections due to Escherichia coli developed. Polymorphonuclear leukocytic functions and monocytic chemotaxis were normal. Killing of E coli and Staphylococcus aureus by the patient's monocytes was impaired. This defect persisted after the infections were successfully treated and the treatment with antimicrobial agents was discontinued. Stimulated nitro blue tetrazolium reduction by the patient's monocytes was normal, suggesting that the microbicidal defect was not in the oxygen-dependent microbicidal system. Total lysozymal content of patient's monocytes was normal. Thus, the basis for this microbicidal defect is still undefined.
对一名患有软斑病的患者的白细胞功能进行了研究，该患者的软斑病累及尿路和腹膜后腔，并出现了由大肠杆菌引起的顽固性感染。多形核白细胞功能和单核细胞趋化性正常。患者单核细胞对大肠杆菌和金黄色葡萄球菌的杀伤作用受损。在感染成功治疗且停用抗菌药物后，这种缺陷仍然存在。患者单核细胞刺激后的硝基蓝四氮唑还原正常，表明杀菌缺陷不在依赖氧的杀菌系统中。患者单核细胞的总溶菌酶含量正常。因此，这种杀菌缺陷的原因仍不明确。
