Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Rev Paul Pediatr. 2022 Sep 9;41:e2021360. doi: 10.1590/1984-0462/2023/41/2021360. eCollection 2022.
The aim of this study was to evaluate the influence of early exposure to agricultural pesticides and their relationship with autism spectrum disorder.
This systematic review was registered at PROSPERO as CRD42020204842. The subject was systematically analyzed on PubMed, Scopus, and Web of Science databases until April 2021. Only studies with humans with early exposure to agricultural pesticides and diagnosis of autism were included. Exclusion criteria were studies on pesticides for domestic or veterinary use and late exposure. There were no language and time restriction. The quality analysis of the studies used the Newcastle-Ottawa Scale.
Six case-control studies were included; three of them measured the route of exposure by maternal biomarkers and the others by the residence address. The studies had scores between moderate and high in the quality assessment tool. It was found high rates of association between early exposure to agricultural pesticides and autism and detection limit above the quantification for a sample of polychlorinated biphenyls, hexachlorobenzene, and dichlorodiphenyldichloroethylene.
There is evidence concerning the exposure to agricultural pesticides in early life and the development of the autism spectrum disorder; however, more studies are required to better understand their possible association.
本研究旨在评估早期接触农业农药及其与自闭症谱系障碍的关系。
本系统评价已在 PROSPERO 上注册，注册号为 CRD42020204842。该主题在 PubMed、Scopus 和 Web of Science 数据库中进行了系统分析，截至 2021 年 4 月。仅纳入了早期接触农业农药且诊断为自闭症的人类研究。排除标准为家庭或兽医用农药和晚期暴露的研究。无语言和时间限制。研究的质量分析使用了纽卡斯尔-渥太华量表。
共纳入 6 项病例对照研究；其中 3 项通过母体生物标志物测量暴露途径，其他 3 项通过居住地址测量暴露途径。这些研究在质量评估工具中的评分在中等和高水平之间。研究发现，早期接触农业农药与自闭症之间存在高度关联，并且在多氯联苯、六氯苯和二氯二苯二氯乙烯的样本中检测到高于定量限的浓度。
有证据表明，早期接触农业农药与自闭症谱系障碍的发生有关；然而，需要更多的研究来更好地了解它们之间可能的关联。
