Ni Pufan, Yang Lei, Shen Yi, Zhang Lei, Ma Yueyue, Sun Maolin, Cheng Ruihua, Ye Jinxing
Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
J Org Chem. 2022 Oct 7;87(19):12677-12687. doi: 10.1021/acs.joc.2c01133. Epub 2022 Sep 14.
A general method for the synthesis of phenols from electron-deficient aryl ammonium salts or heteroaryl ammonium salts under mild conditions was developed. Benzaldehyde oxime, acetohydroxamic acid, and hydroxylamine hydrochloride were investigated as hydroxide surrogates respectively. With these hydroxide surrogates, a series of phenols were prepared in yields of 20-98%.
开发了一种在温和条件下由缺电子芳基铵盐或杂芳基铵盐合成酚类的通用方法。分别研究了苯甲醛肟、乙酰氧肟酸和盐酸羟胺作为氢氧化物替代物。使用这些氢氧化物替代物，制备了一系列酚类，产率为20-98%。
