Hu Xuan-Bo, Fu Qian-Qian, Huang Xue-Ying, Chu Xue-Qiang, Shen Zhi-Liang, Miao Chengping, Chen Weiyi
Technical Institute of Fluorochemistry (TIF), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
College of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China.
Molecules. 2024 Feb 13;29(4):831. doi: 10.3390/molecules29040831.
Hydroxylation of aryl sulfonium salts could be realized by utilizing acetohydroxamic acid and oxime as hydroxylative agents in the presence of cesium carbonate as a base, leading to a variety of structurally diverse hydroxylated arenes in 47-95% yields. In addition, the reaction exhibited broad functionality tolerance, and a range of important functional groups (e.g., cyano, nitro, sulfonyl, formyl, keto, and ester) could be well amenable to the mild reaction conditions.
在碳酸铯作为碱的存在下，利用乙酰氧肟酸和肟作为羟基化试剂，可以实现芳基锍盐的羟基化反应，从而以47-95%的产率得到各种结构多样的羟基化芳烃。此外，该反应表现出广泛的官能团耐受性，一系列重要的官能团（如氰基、硝基、磺酰基、甲酰基、酮基和酯基）都能很好地适应温和的反应条件。
