Ziemsen B, Angerer J, Lehnert G
Int Arch Occup Environ Health. 1987;59(4):413-7. doi: 10.1007/BF00405285.
A cytogenetic study was performed on 20 healthy workers exposed to pentachlorophenol (PCP) in concentrations ranging from 1.2 to 180 micrograms/m3 (Maximum Concentration at the workplace is 500 micrograms/m3) for 3 to 34 years. PCP was determined in the blood plasma of all probands, yielding concentrations between 23 and 775 micrograms/l (Biological Tolerance Value is 1000 micrograms/l). In vitro PCP up to 90 mg/l was added to phytohaemagglutinin stimulated lymphocytes of normal healthy donors without any effect on sister chromatid exchange (SCE) or chromosomal aberrations (CA), whereas a slowdown of cell proliferation could be detected in the presence of 60 mg PCP/l. In vivo we neither observed a relation between PCP concentrations and the number of SCE nor an increase of CA.
对20名健康工人进行了细胞遗传学研究，这些工人接触五氯苯酚（PCP）的浓度范围为1.2至180微克/立方米（工作场所的最大浓度为500微克/立方米），接触时间为3至34年。测定了所有先证者血浆中的五氯苯酚，其浓度在23至775微克/升之间（生物耐受值为1000微克/升）。在体外，向正常健康供体的植物血凝素刺激淋巴细胞中添加高达90毫克/升的五氯苯酚，对姐妹染色单体交换（SCE）或染色体畸变（CA）没有任何影响，而在存在60毫克五氯苯酚/升的情况下可检测到细胞增殖放缓。在体内，我们既未观察到五氯苯酚浓度与SCE数量之间的关系，也未观察到CA的增加。
