Yan Lumiao, Zheng Chen, Yuan Ding, Guo Zhengxi, Cui Yihao, Xie Zhijian, Chen Zhi, Tang Ruikang, Liu Zhaoming
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Disease of Zhejiang province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang university, Hangzhou, Zhejiang, 310006, China.
Adv Healthc Mater. 2022 Dec;11(23):e2201161. doi: 10.1002/adhm.202201161. Epub 2022 Sep 22.
The organic-inorganic structure in biological hard tissues ensures their marvelous characteristics but these hybrids are easily destroyed by the demineralization of inorganic components, e.g., the damage of dentin. Current clinical materials for hard tissue regeneration commonly act as "fillers" and their therapeutic effect is limited by the failures of biological-linked organic-inorganic interface reconstruction. Herein, a fast in situ crosslinking of calcium phosphate oligomers (CPOs) on collagen matrixes for efficient organic-inorganic interface re-construction, which can result in a biomimetic hybrid, is demonstrated. By using damaged dentin as an example, the inorganic ionic crosslinking can instantly infiltrate into the dentin matrix to rebuild a dense and continuous calcium phosphate-collagen hybrid within only 5 min, where the structurally integrated organic-inorganic interface is identical to natural dentin. As a result, the damaged dentin can be fully recovered to a healthy one, which is superior to any current dentin treatments. The fast construction of biomimetic hybrid by inorganic ionic crosslinking provides a promising strategy for hard tissue repair and follows great potentials of CPOs as advanced biomedical materials in future.
生物硬组织中的有机-无机结构赋予了它们非凡的特性，但这些杂化结构很容易因无机成分的脱矿作用而遭到破坏，比如牙本质的损伤。目前用于硬组织再生的临床材料通常起“填充剂”的作用，其治疗效果受到生物连接的有机-无机界面重建失败的限制。在此，展示了一种在胶原基质上快速原位交联磷酸钙低聚物（CPOs）以实现高效有机-无机界面重建的方法，该方法可形成一种仿生杂化材料。以受损牙本质为例，无机离子交联能够在仅5分钟内迅速渗透到牙本质基质中，重建出致密且连续的磷酸钙-胶原杂化结构，其结构完整的有机-无机界面与天然牙本质相同。结果，受损牙本质能够完全恢复至健康状态，这优于目前任何牙本质治疗方法。通过无机离子交联快速构建仿生杂化材料为硬组织修复提供了一种有前景的策略，并展现了CPOs作为先进生物医学材料在未来的巨大潜力。
