Wang Jie, Liu Qiqi, Guo Zhengxi, Pan Haihua, Liu Zhaoming, Tang Ruikang
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China.
Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China.
ACS Biomater Sci Eng. 2023 Apr 10;9(4):1757-1773. doi: 10.1021/acsbiomaterials.1c01070. Epub 2021 Dec 6.
Biomineralization is a process in which natural organisms regulate the crystal growth of inorganic minerals, resulting in hierarchical structured biominerals with excellent properties. Typical biominerals in the human body are the bones and teeth, and damage to these hard tissues directly affect our daily lives. The repair of bones and teeth in a biomimetic way, either by using a biomimetic mineralization strategy or biomimetic materials, is the key for hard tissue regeneration. In this review, we briefly introduce the structure of bone and tooth, and highlight the fundamental role of collagen mineralization in tissue repair. The recent progress on intra-/extrafibrillar collagen mineralization by a biomimetic strategy or materials is presented, and their potential for tissue regeneration is discussed. Then, recent achievements on bone and tooth repair are summarized, and these works are discussed in the view of materials science and biological science, providing a broader vision for the future research of hard tissue repair techniques. Lastly, recent progress on hard tissue regeneration is concluded, and existing problems and future directions are prospected.
生物矿化是一个自然生物体调节无机矿物质晶体生长的过程，从而产生具有优异性能的分级结构生物矿物。人体中的典型生物矿物是骨骼和牙齿，这些硬组织的损伤直接影响我们的日常生活。以仿生方式修复骨骼和牙齿，无论是使用仿生矿化策略还是仿生材料，都是硬组织再生的关键。在这篇综述中，我们简要介绍骨骼和牙齿的结构，并强调胶原矿化在组织修复中的重要作用。介绍了通过仿生策略或材料实现的纤维内/纤维外胶原矿化的最新进展，并讨论了它们在组织再生方面的潜力。然后，总结了骨骼和牙齿修复的最新成果，并从材料科学和生物学的角度对这些工作进行了讨论，为硬组织修复技术的未来研究提供了更广阔的视野。最后，总结了硬组织再生的最新进展，并展望了存在的问题和未来的方向。
