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腹侧脂肪组织厚度和生长分化因子 15 在轴性脊柱关节炎中的相关性:一项横断面研究。

Epicardial adipose tissue thickness and growth differentiation factor 15 in axial spondyloarthritis: A cross-sectional study.

机构信息

From the Department of Physical Medicine and Rehabilitation (Okçu), Marmara University Faculty of Medicine, Istanbul; from the Department of Physical Medicine and Rehabilitation (Koçak), Kırsehir Ahi Evran University Faculty of Medicine; from the Department of Physical Medicine and Rehabilitation (Şaş), Division of Rheumatology, Kayseri, Erciyes University Faculty of Medicine; and from the Department of Biochemistry (Güçlü), Kırsehir Ahi Evran University Faculty of Medicine, Kırsehir, Turkey.

出版信息

Saudi Med J. 2022 Sep;43(9):1020-1026. doi: 10.15537/smj.2022.43.9.20220304.

Abstract

OBJECTIVES

To investigate growth differentiation factor-15 (GDF-15) levels and the thickness of epicardial adipose tissue (EAT) in patients with axial spondyloarthritis (axSpA) and to evaluate their relationship with functional status, disease activity, disease duration, and the type of medical treatment received by the patients.

METHODS

This cross-sectional study was carried out at Kırşehir Ahievran University School of Medicine between February and June 2020. Twenty-nine healthy controls and 44 patients with axSpA were included in the study. Gender, age, erythrocyte sedimentation rate, GDF-15, body mass index, complete blood count, ejection fraction, the EAT thickness, and C-reactive protein of all participants were recorded. Ankylosing Spondylitis Quality of Life Index, Bath Ankylosing Spondylitis Functional Index, the disease duration, Bath Ankylosing Spondylitis Metrology Index, and Bath Ankylosing Spondylitis Disease Activity Index scores of patients with axSpA were noted.

RESULTS

Epicardial adipose tissue thickness values (0.35±0.09 cm) in the AxSpA group were higher compared to the control group (0.26±0.06 cm) (<0.01). Growth differentiation factor-15 levels of the control group and axSpA group were similar. The treatment received by the patients did not have a significant relationship with EAT thickness and GDF-15. Bath Ankylosing Spondylitis Functional Index scores, disease duration, and age were significantly positively correlated with GDF-15 levels.

CONCLUSION

In this study, EAT thickness values were found to be significantly higher in the axSpA group. In addition, GDF-15 was positively correlated with age, Bath Ankylosing Spondylitis Functional Index score, and disease duration.

摘要

目的

研究生长分化因子-15(GDF-15)水平和心外膜脂肪组织(EAT)厚度在轴性脊柱关节炎(axSpA)患者中的变化,并评估其与功能状态、疾病活动度、疾病持续时间以及患者接受的治疗类型的关系。

方法

本横断面研究于 2020 年 2 月至 6 月在基尔希埃雷夫兰大学医学院进行。共纳入 29 名健康对照者和 44 名 axSpA 患者。记录所有参与者的性别、年龄、红细胞沉降率、GDF-15、体重指数、全血细胞计数、射血分数、EAT 厚度和 C 反应蛋白。记录 axSpA 患者的强直性脊柱炎生活质量指数、巴斯强直性脊柱炎功能指数、疾病持续时间、巴斯强直性脊柱炎测量指数和巴斯强直性脊柱炎疾病活动指数评分。

结果

axSpA 组的 EAT 厚度值(0.35±0.09 cm)高于对照组(0.26±0.06 cm)(<0.01)。对照组和 axSpA 组的 GDF-15 水平相似。患者接受的治疗与 EAT 厚度和 GDF-15 无显著关系。Bath 强直性脊柱炎功能指数评分、疾病持续时间和年龄与 GDF-15 水平呈显著正相关。

结论

在本研究中,axSpA 组的 EAT 厚度值显著升高。此外,GDF-15 与年龄、Bath 强直性脊柱炎功能指数评分和疾病持续时间呈正相关。

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本文引用的文献

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