Department of Oral Medicine, Seoul National University Dental Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Department of Oral Medicine and Oral Diagnosis, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
BMC Oral Health. 2022 Sep 14;22(1):401. doi: 10.1186/s12903-022-02428-3.
Temporomandibular disorders (TMD) is a disease characterized by pain and dysfunction of the masticatory muscles and temporomandibular joint. Many factors have been found to be related to the disease however, the underlying mechanism is yet to be fully elucidated. Physical activity is widely known to modulate pain intensity in various pain disorders. However, literature suggesting the association between physical activity and signs and symptoms of TMD are limited.
The "Physical Activity in TMD (PAT)" is a prospective study on TMD patients that aims to determine how daily physical activity and sleep duration affect long-term TMD prognosis following conventional treatment. To analyze such effects, objective data on daily physical activity levels will be collected along with clinical indices including mouth opening ranges and masticatory muscle palpation responses from adult Koreans diagnosed with TMD following standardized diagnostic procedures. Well-known comorbidities of TMD will be extensively evaluated based on validated structured questionnaires on sleep quality, fatigue level, widespread pain, psychological status including depression and anxiety, autonomic symptoms, and health-related quality of life. The collected data will be analyzed according to TMD pain severity and physical activity level, and correlations among physical activity indices and long-term TMD prognosis will be investigated.
In this longitudinal prospective study of adult Koreans diagnosed with TMD following standardized diagnostic procedures, primary outcomes include physical activity levels and long-term TMD clinical outcomes and secondary outcomes include disability from pain and related comorbidity levels. Results and analysis are ongoing. The results of this study will provide reliable data for future research and establish clinical guidelines that will allow cause-related, patient-tailored personalized medicine for TMD.
Clinical Research Information Service (Registration number: KCT0007107). Registered March 22 2022 https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=M&pageSize=10&page=undefined&seq=21420&status=5&seq_group=21420 .
颞下颌关节紊乱（TMD）是一种以咀嚼肌和颞下颌关节疼痛和功能障碍为特征的疾病。许多因素已被发现与该疾病有关，但发病机制尚未完全阐明。运动已被广泛认为可以调节各种疼痛疾病的疼痛强度。然而，关于运动与 TMD 体征和症状之间的关联的文献有限。
“颞下颌关节紊乱中的体力活动（PAT）”是一项针对 TMD 患者的前瞻性研究，旨在确定日常体力活动和睡眠时间如何影响常规治疗后 TMD 的长期预后。为了分析这些影响，将从经过标准化诊断程序诊断为 TMD 的成年韩国人中收集有关日常体力活动水平的客观数据，以及包括开口范围和咀嚼肌触诊反应在内的临床指标。将根据关于睡眠质量、疲劳水平、广泛疼痛、包括抑郁和焦虑在内的心理状态、自主症状和健康相关生活质量的经过验证的结构化问卷，广泛评估 TMD 的常见合并症。收集的数据将根据 TMD 疼痛严重程度和体力活动水平进行分析，并研究体力活动指标与长期 TMD 预后之间的相关性。
在这项针对经过标准化诊断程序诊断为 TMD 的成年韩国人的纵向前瞻性研究中，主要结局包括体力活动水平和 TMD 的长期临床结局，次要结局包括疼痛相关残疾和相关合并症水平。结果和分析正在进行中。该研究的结果将为未来的研究提供可靠的数据，并为 TMD 制定基于病因的、针对患者的个性化医学临床指南。
临床研究信息服务（注册号：KCT0007107）。2022 年 3 月 22 日注册 https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=M&pageSize=10&page=undefined&seq=21420&status=5&seq_group=21420。
