关于肾脏疾病中的外泌体微小RNA，我们实际上了解多少？
What do we actually know about exosomal microRNAs in kidney diseases?
作者信息
Li Qianyu, Zhang Zhiping, Yin Min, Cui Cancan, Zhang Yucheng, Wang Yali, Liu Feng
机构信息
Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, China.
Clinical Laboratory, China-Japan Union Hospital of Jilin University, Changchun, China.
出版信息
Front Physiol. 2022 Aug 29;13:941143. doi: 10.3389/fphys.2022.941143. eCollection 2022.
There are several types of kidney diseases with complex causes. If left untreated, these diseases irreversibly progress to end-stage renal disease. Thus, their early diagnosis and targeted treatment are important. Exosomes-extracellular vesicles released by a variety of cells-are ideal carriers for DNA, RNA, proteins, and other metabolites owing to their bilayer membranes. Studies have shown that almost all renal cells can secrete exosomes. While research on exosomal microRNAs in the context of renal diseases begun only recently, rapid progress has been achieved. This review summarizes the changes in exosomal microRNA expression in different kidney diseases. Thus, it highlights the diagnostic and prognostic value of these exosomal microRNAs. Further, this review analyzes their roles in the development of different kidney diseases, guiding research on molecular mechanisms and therapeutic strategies.
有几种病因复杂的肾脏疾病。如果不加以治疗，这些疾病会不可逆转地发展为终末期肾病。因此，对它们进行早期诊断和靶向治疗很重要。外泌体——由多种细胞释放的细胞外囊泡——由于其双层膜，是DNA、RNA、蛋白质和其他代谢物的理想载体。研究表明，几乎所有肾细胞都能分泌外泌体。虽然最近才开始在肾脏疾病背景下对外泌体微小RNA进行研究，但已取得了迅速进展。这篇综述总结了不同肾脏疾病中外泌体微小RNA表达的变化。因此，它突出了这些外泌体微小RNA的诊断和预后价值。此外，这篇综述分析了它们在不同肾脏疾病发展中的作用，为分子机制和治疗策略的研究提供指导。
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