Deen Surrin S, McLean Mary A, Gill Andrew B, Crawford Robin A F, Latimer John, Baldwin Peter, Earl Helena M, Parkinson Christine A, Smith Sarah, Hodgkin Charlotte, Jimenez-Linan Mercedes, Brodie Cara R, Patterson Ilse, Addley Helen C, Freeman Susan J, Moyle Penelope M, Graves Martin J, Sala Evis, Brenton James D, Gallagher Ferdia A
Department of Radiology, Box 218, University of Cambridge, Cambridge, United Kingdom, CB2 0QQ.
Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ.
BJR Open. 2022 May 2;4(1):20210078. doi: 10.1259/bjro.20210078. eCollection 2022.
To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy (NACT).
This was a prospective observational study. 12 HGSOC patients were imaged before treatment. MTR was compared to quantified tissue histology and immunohistochemistry. For a subset of patients ( = 5), MT imaging was repeated after NACT. The Shapiro-Wilk test was used to assess for normality of data and Spearman's rank-order or Pearson's correlation tests were then used to compare MTR with tissue quantifications. The Wilcoxon signed-rank test was used to assess for changes in MTR after treatment.
Treatment-naïve tumour MTR was 21.9 ± 3.1% (mean ± S.D.). MTR had a positive correlation with cellularity, rho = 0.56 ( < 0.05) and a negative correlation with tumour volume, ρ = -0.72 ( = 0.01). MTR did not correlate with the extracellular proteins, collagen IV or laminin ( = 0.40 and = 0.90). For those patients imaged before and after NACT, an increase in MTR was observed in each case with mean MTR 20.6 ± 3.1% (median 21.1) pre-treatment and 25.6 ± 3.4% (median 26.5) post-treatment ( = 0.06).
In treatment-naïve HGSOC, MTR is associated with cellularity, possibly reflecting intracellular macromolecular concentration. MT may also detect the HGSOC response to NACT, however larger studies are required to validate this finding.
MTR in HGSOC is influenced by cellularity. This may be applied to assess for cell changes following treatment.
研究高级别浆液性卵巢癌（HGSOC）中磁化传递（MT）成像与组织大分子之间的关系，以及新辅助化疗（NACT）后MT比率（MTR）是否发生变化。
这是一项前瞻性观察性研究。12例HGSOC患者在治疗前进行成像。将MTR与定量组织学和免疫组织化学进行比较。对于一部分患者（n = 5），在NACT后重复进行MT成像。使用Shapiro-Wilk检验评估数据的正态性，然后使用Spearman等级相关或Pearson相关检验比较MTR与组织定量。使用Wilcoxon符号秩检验评估治疗后MTR的变化。
未经治疗的肿瘤MTR为21.9±3.1%（平均值±标准差）。MTR与细胞密度呈正相关，rho = 0.56（P < 0.05），与肿瘤体积呈负相关，ρ = -0.72（P = 0.01）。MTR与细胞外蛋白、IV型胶原或层粘连蛋白无相关性（P = 0.40和P = 0.90）。对于那些在NACT前后进行成像的患者，每例均观察到MTR升高，治疗前平均MTR为20.6±3.1%（中位数21.1），治疗后为25.6±3.4%（中位数26.5）（P = 0.06）。
在未经治疗的HGSOC中，MTR与细胞密度相关，可能反映细胞内大分子浓度。MT也可能检测到HGSOC对NACT的反应，然而需要更大规模的研究来验证这一发现。
HGSOC中的MTR受细胞密度影响。这可用于评估治疗后的细胞变化。
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