在质子转移 (APT) 和磁化转移 (MT) MRI 对比中，质子磁共振波谱成像 (MRSI) 同样为脑肿瘤提供了互补性评估。
Amid proton transfer (APT) and magnetization transfer (MT) MRI contrasts provide complimentary assessment of brain tumors similarly to proton magnetic resonance spectroscopy imaging (MRSI).
机构信息
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, Hankou, Wuhan, 430030, People's Republic of China.
The Department of Radiology and Bioengineering, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
出版信息
Eur Radiol. 2019 Mar;29(3):1203-1210. doi: 10.1007/s00330-018-5615-8. Epub 2018 Aug 13.
OBJECTIVES
Using MRSI as comparison, we aimed to explore the difference between amide proton transfer (APT) MRI and conventional semi-solid magnetization transfer ratio (MTR) MRI, and to investigate if molecular APT and structural MTR can provide complimentary information in assessing brain tumors.
METHODS
Seventeen brain tumor patients and 17 age- and gender-matched volunteers were included and scanned with anatomical MRI, APT and MT-weighted MRI, and MRSI. Multi-voxel choline (Cho) and N-acetylaspartic acid (NAA) signals were quantified from MRSI and compared with MTR and MTR contrasts averaged from corresponding voxels. Correlations between contrasts were explored voxel-by-voxel by pooling values from all voxels into Pearson's correlation analysis. Differences in correlation coefficients were tested with the Z-test (set at p<0.05).
RESULTS
APT and MT provide good contrast and quantitative parameters in tumor imaging, as do the metabolite (Cho and NAA) maps. MTR significantly correlated with MTR (R=-0.61, p<0.0001), Cho (R=0.568, p<0.0001) and NAA (R=-0.619, p<0.0001) in tumors, and MTR also significantly correlated with Cho (R=-0.346, p<0.0001) and NAA (R=0.624, p<0.0001). In healthy volunteers, MTR was non-significantly correlated with MTR (R=-0.049, p=0.239), Cho (R=0.030, p=0.478) and NAA (R=-0.083, p=0.046). Significant correlations were found among MTR with Cho (R=0.199, p<0.0001) and NAA (R=0.263, p<0.0001) in the group of healthy volunteers with lower correlation R values than those in tumor patients.
CONCLUSIONS
APT and MT could provide independent and supplementary information for the comprehensive assessment of molecular and structural changes due to brain tumor cancerogenesis.
KEY POINTS
• MTR positively correlated with Cho while negatively with NAA in tumors. • MTR positively correlated with NAA while negatively with Cho in tumors. • Combining APT/MT provides molecular and structural information similarly to MRSI.
目的
以磁共振波谱成像（MRSI）为对照，我们旨在探索酰胺质子转移（APT）MRI 与传统半固态磁化传递率（MTR）MRI 之间的差异，并研究分子 APT 和结构 MTR 是否可以提供互补信息来评估脑肿瘤。
方法
纳入 17 例脑肿瘤患者和 17 名年龄和性别匹配的志愿者，并进行解剖 MRI、APT 和 MT 加权 MRI 以及 MRSI 扫描。从 MRSI 中定量多体素胆碱（Cho）和 N-乙酰天门冬氨酸（NAA）信号，并将其与相应体素的 MTR 和 MTR 对比进行比较。通过将所有体素的值汇集到 Pearson 相关分析中，对体素进行了对比。使用 Z 检验（设定 p<0.05）测试了相关系数的差异。
结果
APT 和 MT 在肿瘤成像中提供了良好的对比度和定量参数，代谢物（Cho 和 NAA）图谱也是如此。MTR 与肿瘤中的 MTR（R=-0.61，p<0.0001）、Cho（R=0.568，p<0.0001）和 NAA（R=-0.619，p<0.0001）显著相关，MTR 还与 Cho（R=-0.346，p<0.0001）和 NAA（R=0.624，p<0.0001）显著相关。在健康志愿者中，MTR 与 MTR（R=-0.049，p=0.239）、Cho（R=0.030，p=0.478）和 NAA（R=-0.083，p=0.046）无显著相关性。在健康志愿者中，MTR 与 Cho（R=0.199，p<0.0001）和 NAA（R=0.263，p<0.0001）之间存在显著相关性，其相关 R 值低于肿瘤患者。
结论
APT 和 MT 可为分子和结构变化的综合评估提供独立和补充信息，这些变化是由于脑肿瘤的癌变引起的。
关键点
• MTR 在肿瘤中与 Cho 呈正相关，与 NAA 呈负相关。
• MTR 在肿瘤中与 NAA 呈正相关，与 Cho 呈负相关。
• 结合 APT/MT 可提供类似于 MRSI 的分子和结构信息。
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