Rahi A, Ashton N
Br J Ophthalmol. 1978 Sep;62(9):627-43. doi: 10.1136/bjo.62.9.627.
The present study is the first investigation to demonstrate, by employing the combined approach of immunologically and electron microscope methods, the presence of actin-like contractile proteins in the mammalian retina, the corneal epithelium and endothelium, the iris, and the ciliary body, and to confirm their presence in lens epithelium. This is also the first report to demonstrate by these methods the presence of microfilaments and intermediate filaments in retinal vascular endothelium. Since we have shown that actin filaments are especially abundant in immature retinal endothelial cells, the question of their function arises, and we have discussed their possible relevance to the closure of immature retinal vessels when exposed to hyperoxia.
本研究首次采用免疫和电子显微镜相结合的方法，证实了肌动蛋白样收缩蛋白在哺乳动物视网膜、角膜上皮和内皮、虹膜及睫状体中的存在，并进一步确认其在晶状体上皮中的存在。这也是首次通过这些方法证实视网膜血管内皮中存在微丝和中间丝。鉴于我们已表明肌动蛋白丝在未成熟视网膜内皮细胞中尤为丰富，其功能问题随之而来，我们还讨论了在高氧环境下，它们与未成熟视网膜血管闭合的可能关联。
