Schick M P, Schick R O, Richardson J A
J Am Vet Med Assoc. 1987 Jul 15;191(2):207-11.
Accidental exposure of the skin of a dog to a commercial hygroscopic landscaping product (77-80% CaCl2) caused contact-irritant dermatitis within 24 hours. Papules and eroded to ulcerated plaques with hyperproliferative margins developed on various areas of the skin that had come in contact with CaCl2. Histopathologic findings were typical of calcinosis cutis. Reproducible lesions similar to those observed on the referred dog were induced on 5 clinically normal dogs exposed to small amounts of the compound. Histopathologic documentation of the percutaneous penetration of CaCl2, with evidence of calcinosis cutis, was found in the dogs as early as 24 hours after continuous skin contact with the offending substance. Electron-microscopic evidence of crystalline deposits within dermal collagen also was found in skin biopsy specimens obtained 24 hours after contact with CaCl2. Serum calcium and phosphorus concentrations in the 5 dogs remained within normal limits before and after topical application of CaCl2.
一只狗的皮肤意外接触到一种商业吸湿园林产品（77 - 80%氯化钙），在24小时内引发了接触刺激性皮炎。在与氯化钙接触的皮肤各个部位出现了丘疹，以及糜烂至溃疡的斑块，边缘增生。组织病理学检查结果为皮肤钙质沉着症的典型表现。在5只临床正常的狗身上涂抹少量该化合物后，诱发了与上述狗身上观察到的类似的可重复性病变。早在与该有害物质持续皮肤接触24小时后，在这些狗身上就发现了氯化钙经皮渗透的组织病理学证据以及皮肤钙质沉着症的迹象。在接触氯化钙24小时后获取的皮肤活检标本中，还发现了真皮胶原内结晶沉积物的电子显微镜证据。在5只狗局部应用氯化钙前后，血清钙和磷浓度均保持在正常范围内。
