Department of Obstetrics and Gynecology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Obstetrics and Gynecology, Shanghai Songjiang District Maternal and Child Health Hospital, Shanghai, China.
Pathol Oncol Res. 2022 Aug 30;28:1610554. doi: 10.3389/pore.2022.1610554. eCollection 2022.
Identification of novel biomarkers is helpful for the diagnosis and treatment of cervical cancer. Mucin glycosylating enzyme GALNT2 modulates mucin O-glycosylation, and has been revealed as a regulator of tumorigenesis in various cancers. However, the expression pattern of GALNT2 in cervical cancer is still unclear. In this study, we demonstrated that the mRNA expression and protein level of GALNT2 were increased in cervical high-grade intraepithelial neoplasia and tumor tissues compared with normal cervix tissues. Kaplan-Meier plotter showed that overexpression of GALNT2 was associated with worse overall survival in TCGA cohort ( < 0.001, HR = 2.65, 95% CI = 1.62-4.34) and poor disease free survival in GSE44001 cohort ( = 0.0218, HR = 2.15, 95% CI = 1.14-4.06). In addition, GSEA analysis showed that various immune-related pathways were closely related to the expression of GALNT2 in cervical cancer. Moreover, co-expression of GALNT2 and IL1A, IL1B, IL11, CXCL1, CXCL2, CXCL5, CXCL6, CXCR1, or CCR3 predicted poor overall survival, and the expression of GALNT2 also affected the prognostic value of CD47, CD274, CD276, CSF1R, TNFSF9, and TNFSF11 in cervical cancer patients. These findings suggest that GALNT2 might be used as a prognostic biomarker in cervical cancer.
鉴定新的生物标志物有助于宫颈癌的诊断和治疗。糖基转移酶 GALNT2 调节粘蛋白 O-糖基化，已被揭示为多种癌症发生的调节剂。然而，GALNT2 在宫颈癌中的表达模式尚不清楚。在这项研究中，我们证明与正常宫颈组织相比，宫颈高级别上皮内瘤变和肿瘤组织中 GALNT2 的 mRNA 表达和蛋白水平增加。Kaplan-Meier 绘图器显示，TCGA 队列中 GALNT2 的过表达与总生存期较差相关（<0.001，HR=2.65，95%CI=1.62-4.34），GSE44001 队列中无病生存期较差（=0.0218，HR=2.15，95%CI=1.14-4.06）。此外，GSEA 分析表明，各种免疫相关途径与宫颈癌中 GALNT2 的表达密切相关。此外，GALNT2 与 IL1A、IL1B、IL11、CXCL1、CXCL2、CXCL5、CXCL6、CXCR1 或 CCR3 的共表达预测总生存期较差，并且 GALNT2 的表达也影响了 CD47、CD274、CD276、CSF1R、TNFSF9 和 TNFSF11 在宫颈癌患者中的预后价值。这些发现表明 GALNT2 可能作为宫颈癌的预后生物标志物。
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