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难治性胃十二指肠溃疡：布卢姆综合征的一种罕见并发症。

Refractory gastroduodenal ulcers: A rare complication with Bloom syndrome.

作者信息

Usami Masaaki, Ikawa Yasuhiro, Sakai Yuta, Fujiki Toshihiro, Wada Taizo

机构信息

Department of Pediatrics School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University Kanazawa Japan.

出版信息

Clin Case Rep. 2022 Sep 12;10(9). doi: 10.1002/ccr3.6141. eCollection 2022 Sep.

DOI:10.1002/ccr3.6141
PMID:36110332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9465695/
Abstract

Bloom syndrome patients often develop severe gastrointestinal symptoms mainly caused by gastric tumors due to DNA repair disorder. Here, we report 31-year-old Bloom syndrome patient suffering persistent abdominal pain due to refractory gastroduodenal ulcers which required gastroduodenectomy. Various causes should be considered, and the accumulation of their reports is warranted.

摘要

布卢姆综合征患者常出现严重的胃肠道症状，主要由DNA修复障碍导致的胃部肿瘤引起。在此，我们报告一名31岁的布卢姆综合征患者，因难治性胃十二指肠溃疡持续腹痛，需行胃十二指肠切除术。应考虑各种原因，且有必要积累相关病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/5273159b284b/CCR3-10--g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/d9482f1d0f1d/CCR3-10--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/eb2928d4ea2b/CCR3-10--g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/b90b358bddbf/CCR3-10--g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/5273159b284b/CCR3-10--g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/d9482f1d0f1d/CCR3-10--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/eb2928d4ea2b/CCR3-10--g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/b90b358bddbf/CCR3-10--g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64a/9465695/5273159b284b/CCR3-10--g002.jpg

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本文引用的文献

1
Bloom syndrome and the underlying causes of genetic instability.布卢姆综合征与遗传不稳定性的潜在病因。
Mol Genet Metab. 2021 May;133(1):35-48. doi: 10.1016/j.ymgme.2021.03.003. Epub 2021 Mar 10.
2
Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms.以早发性炎症性肠病为模型疾病，鉴定免疫稳态机制的关键调节因子。
Immunol Rev. 2019 Jan;287(1):162-185. doi: 10.1111/imr.12726.
3
Health supervision for people with Bloom syndrome.布卢姆综合征患者的健康监督。
Am J Med Genet A. 2018 Sep;176(9):1872-1881. doi: 10.1002/ajmg.a.40374. Epub 2018 Jul 28.
4
Novel ZBTB24 Mutation Associated with Immunodeficiency, Centromere Instability, and Facial Anomalies Type-2 Syndrome Identified in a Patient with Very Early Onset Inflammatory Bowel Disease.在一位极早发性炎症性肠病患者中发现的与免疫缺陷、着丝粒不稳定和颜面异常 2 型综合征相关的新型 ZBTB24 突变。
Inflamm Bowel Dis. 2017 Dec;23(12):2252-2255. doi: 10.1097/MIB.0000000000001280.
5
Surgical perspectives in peptic ulcer disease and gastritis.消化性溃疡病和胃炎的外科治疗观点
World J Gastroenterol. 2006 May 28;12(20):3248-52. doi: 10.3748/wjg.v12.i20.3248.
6
Ulcerative colitis complicated by dysplasia-adenoma-carcinoma in a man with Bloom's syndrome.
J Clin Gastroenterol. 1999 Jun;28(4):380-2. doi: 10.1097/00004836-199906000-00023.
7
Gastrointestinal cytomegalovirus disease.胃肠道巨细胞病毒病
Ann Intern Med. 1993 Nov 1;119(9):924-35. doi: 10.7326/0003-4819-119-9-199311010-00010.
8
The Bloom's syndrome gene product is homologous to RecQ helicases.布卢姆氏综合征基因产物与RecQ解旋酶同源。
Cell. 1995 Nov 17;83(4):655-66. doi: 10.1016/0092-8674(95)90105-1.