Fujiwara Shun, Kawamoto Ami, Motobayashi Maiko, Hibiya Shuji, Takenaka Kento, Shimizu Hiromichi, Saito Eiko, Fujii Toshimitsu, Nagahori Masakazu, Kawata Daisuke, Umezawa Natsuka, Hosoya Tadashi, Yasuda Shinsuke, Ohtsuka Kazuo, Okamoto Ryuichi
Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo Japan.
Endoscopic Unit Tokyo Medical and Dental University Hospital Tokyo Japan.
DEN Open. 2022 Dec 15;3(1):e196. doi: 10.1002/deo2.196. eCollection 2023 Apr.
Behcet's disease (BD) is a multisystem immune-mediated inflammatory disorder that occasionally involves the gastrointestinal tract. Reports on gastrointestinal involvement of BD are relatively rare, of which gastroduodenal involvement is particularly rare. Endoscopic features of gastroduodenal lesions are unknown, and treatment strategies have not been established. In this report, we present the case of a 72-year-old female with gastrointestinal BD who presented with extensive gastroduodenal ulcers and hematemesis that were resistant to colchicine and corticosteroid treatment, which were subsequently successfully treated with infliximab. We also review the current literature on the gastroduodenal involvement of BD. Although rare, the case highlights the importance of being aware of upper gastrointestinal manifestations of BD, as well as demonstrating the potential of infliximab to treat corticosteroid-resistant cases.
白塞病（BD）是一种多系统免疫介导的炎症性疾病，偶尔累及胃肠道。关于BD胃肠道受累的报道相对较少，其中胃十二指肠受累尤为罕见。胃十二指肠病变的内镜特征尚不清楚，治疗策略也未确立。在本报告中，我们介绍了一例72岁女性胃肠道BD患者，该患者出现广泛的胃十二指肠溃疡和呕血，对秋水仙碱和皮质类固醇治疗耐药，随后使用英夫利昔单抗成功治疗。我们还回顾了关于BD胃十二指肠受累的当前文献。尽管罕见，但该病例凸显了认识BD上消化道表现的重要性，同时也证明了英夫利昔单抗治疗皮质类固醇耐药病例的潜力。
