Zhang Xuepeng, Zhang Lifan, Wei Canzheng, Feng Liwei, Yang Juqin, Zhang Geng, Lu Guoyan, Gui Xiying, Zhou Yue, Yang Kaiying, Zhou Jiangyuan, Zhou Xinle, Wang Ruoran, Chen Siyuan, Ji Yi
Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.
Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
Front Nutr. 2022 Aug 30;9:931599. doi: 10.3389/fnut.2022.931599. eCollection 2022.
The detailed association between albumin levels and mortality has not been studied in critically ill children. The aim of this study was to reveal an association between albumin levels in detail and mortality in critically ill children.
We retrospectively collected data from children admitted to four pediatric intensive care units (PICUs) in China between January 2015 and October 2020. Restricted cubic spline curves based on logistic regression models were generated to evaluate the detailed associations between serum albumin levels and PICU mortality. Threshold effect analysis was performed using two piecewise regression models.
The study included 9,123 children. The overall mortality was 5.3%. The detailed association between serum albumin levels and the risk of mortality followed a U-shape. The risk of mortality decreased with increasing serum albumin levels (OR = 0.919; 95% CI: 0.886, 0.954) in children with serum albumin levels < 43.2 g/L and increased with increasing serum albumin levels (OR = 1.174; 95% CI: 1.044, 1.316) in children with serum albumin levels ≥ 43.2 g/L.
There was a U-shaped association between serum albumin levels and mortality in critically ill children in the PICU.
尚未对危重症儿童白蛋白水平与死亡率之间的详细关联进行研究。本研究的目的是详细揭示危重症儿童白蛋白水平与死亡率之间的关联。
我们回顾性收集了2015年1月至2020年10月期间在中国四家儿科重症监护病房（PICU）住院的儿童的数据。基于逻辑回归模型生成受限立方样条曲线，以评估血清白蛋白水平与PICU死亡率之间的详细关联。使用两个分段回归模型进行阈值效应分析。
该研究纳入了9123名儿童。总体死亡率为5.3%。血清白蛋白水平与死亡风险之间的详细关联呈U形。血清白蛋白水平<43.2 g/L的儿童，死亡风险随血清白蛋白水平升高而降低（OR = 0.919；95%CI：0.886，0.954）；血清白蛋白水平≥43.2 g/L的儿童，死亡风险随血清白蛋白水平升高而增加（OR = 1.174；95%CI：1.044，1.316）。
PICU中危重症儿童的血清白蛋白水平与死亡率之间存在U形关联。
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