Chen Jin, Huang Yuan-Lei, Huang Hui, Zheng Tao, Cong Guang-Zhi
Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Department of Cardiology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Front Cardiovasc Med. 2022 Aug 30;9:917325. doi: 10.3389/fcvm.2022.917325. eCollection 2022.
There is no conclusive proven link between ascending aorta diameter (AoD) and the risk of death from heart failure (HF). As a result, a retrospective cohort analysis was carried out to determine whether AoD is associated with 12-month mortality in Chinese HF patients.
From January 2017 to March 2020, we collected data on 575 Chinese patients with HF. The exposure and outcome variables were baseline AoD and 12-month risk of mortality (all-cause + cardiac origin), respectively. Data on demographics, drug usage, clinical characteristics, recognized indicators of HF, and comorbidities were included as covariates. To investigate the independent relationships of AoD with the risk of 12-month death, binary logistic regression and two-piecewise linear models were utilized.
Our findings imply that there was a non-linear relationship between AoD and the risk of 12-month mortality. For the AoD range of 23 to 37, there was no association with the risk of cardiac mortality [odds ratio (OR) 0.78, 95% confidence interval (CI), 0.62-1.04]. In the AoD range of 37-49, however, the risk of 12-month cardiac death increased by approximately 70% for every 1 mm increase in AoD (OR 1.70, 95% CI, 1.13-2.55). When all-cause death was chosen as the outcome, the same outcome was shown.
An AoD larger than 37 mm is a hazardous threshold for Chinese HF patients. Beyond this limit increased the risk of cardiac death by 70% for every 1 mm increase in AoD.
升主动脉直径（AoD）与心力衰竭（HF）死亡风险之间尚无确凿的证实联系。因此，进行了一项回顾性队列分析，以确定AoD是否与中国HF患者的12个月死亡率相关。
2017年1月至2020年3月，我们收集了575例中国HF患者的数据。暴露变量和结局变量分别为基线AoD和12个月死亡风险（全因+心源）。人口统计学、药物使用、临床特征、公认的HF指标和合并症的数据作为协变量纳入。为了研究AoD与12个月死亡风险的独立关系，采用了二元逻辑回归和两段式线性模型。
我们的研究结果表明，AoD与12个月死亡率风险之间存在非线性关系。对于23至37的AoD范围，与心脏死亡风险无关[比值比（OR）0.78，95%置信区间（CI），0.62 - 1.04]。然而，在37 - 49的AoD范围内，AoD每增加1 mm，12个月心脏死亡风险增加约70%（OR 1.70，95% CI，1.13 - 2.55）。当选择全因死亡作为结局时，显示出相同的结果。
对于中国HF患者，AoD大于37 mm是一个危险阈值。超过此限值，AoD每增加1 mm，心脏死亡风险增加70%。
