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Need to focus on inhibitory activity of benzimidazole analogues against indolamine 2,3-dioxygenase-1 (IDO-1).需要关注苯并咪唑类似物对吲哚胺2,3-双加氧酶-1（IDO-1）的抑制活性。
EXCLI J. 2022 Jun 28;21:904-905. doi: 10.17179/excli2022-4988. eCollection 2022.
2
The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition.1-甲基色氨酸异构体对肾缺血再灌注损伤的保护作用并非完全依赖于吲哚胺 2,3-双加氧酶抑制。
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Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties.硫代氨基脲，一种具有潜在吲哚胺-2,3-双加氧酶（IDO）抑制特性的片段。
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Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience.不同类型淋巴瘤中吲哚胺2,3-双加氧酶（IDO）的免疫组化特征：单中心经验
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Decreased expression of indolamine 2,3-dioxygenase in childhood allergic asthma and its inverse correlation with fractional concentration of exhaled nitric oxide.儿童过敏性哮喘中吲哚胺2,3-双加氧酶表达降低及其与呼出一氧化氮分数浓度的负相关
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Serum indolamine 2,3 dioxygenase as a marker in the evaluation of allergic rhinitis.血清吲哚胺2,3-双加氧酶作为评估变应性鼻炎的一项标志物。
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Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies.阻断吲哚胺-2,3-双加氧酶的反弹免疫抑制可增强放射性免疫疗法在小鼠模型和自发性犬类恶性肿瘤中的抗肿瘤效果。
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Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation.吲哚胺2,3-双加氧酶在中枢神经系统中表达，并下调自身免疫性炎症。
FASEB J. 2005 Aug;19(10):1347-9. doi: 10.1096/fj.04-3228fje. Epub 2005 Jun 6.
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Butyrate Produced by Commensal Bacteria Down-Regulates () Expression a Dual Mechanism in Human Intestinal Epithelial Cells.丁酸产生菌通过双重机制下调人肠道上皮细胞 () 的表达。
Front Immunol. 2018 Dec 11;9:2838. doi: 10.3389/fimmu.2018.02838. eCollection 2018.

引用本文的文献

1
Advances in Lung Cancer Treatment Using Nanomedicines.肺癌纳米药物治疗进展
ACS Omega. 2022 Dec 29;8(1):10-41. doi: 10.1021/acsomega.2c04078. eCollection 2023 Jan 10.

本文引用的文献

1
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.发现 IACS-9779 和 IACS-70465 是针对吲哚胺 2,3-双加氧酶 1（IDO1）脱辅基酶的有效抑制剂。
J Med Chem. 2021 Aug 12;64(15):11302-11329. doi: 10.1021/acs.jmedchem.1c00679. Epub 2021 Jul 22.
2
Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.发现咪唑并吡啶类化合物作为吲哚胺2,3-双加氧酶1的强效抑制剂用于癌症免疫治疗
ACS Med Chem Lett. 2021 Mar 2;12(3):494-501. doi: 10.1021/acsmedchemlett.1c00014. eCollection 2021 Mar 11.
3
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to Pharmacodynamic Activity.发现强效苯并咪唑衍生物作为吲哚胺 2,3-双加氧酶-1（IDO1）抑制剂：从基于结构的虚拟筛选到药效活性。
J Med Chem. 2020 Mar 26;63(6):3047-3065. doi: 10.1021/acs.jmedchem.9b01809. Epub 2020 Mar 17.
4
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.一种用于发现吲哚胺 2,3-双加氧酶 1 抑制剂的多组分方法：合成、生物研究和对接研究。
Bioorg Med Chem Lett. 2018 Feb 15;28(4):651-657. doi: 10.1016/j.bmcl.2018.01.032. Epub 2018 Feb 2.

Need to focus on inhibitory activity of benzimidazole analogues against indolamine 2,3-dioxygenase-1 (IDO-1).

作者信息

Sharma Akshansh, Tonk Rajiv, Shekhar Ravi, Dohare Sushil, Kumar Deepak

机构信息

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh 173 229, India.

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University, New Delhi 110017, India.

出版信息

EXCLI J. 2022 Jun 28;21:904-905. doi: 10.17179/excli2022-4988. eCollection 2022.

DOI:10.17179/excli2022-4988
PMID:36110557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9441679/
Abstract
摘要