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三果木与氢氧化钙作为根管内药物抗菌效果的比较评价:一项研究。

A Comparative Evaluation of Antimicrobial Efficacy of Triphala and Calcium Hydroxide as Intracanal Medicament: An Study.

作者信息

Selvi Mathi Muthamil, Selvabalaji Arumugam, Chonat Anagha, Ananthan Vasanthakumari, Mani Ebenezeer, Chinnaswamy Ananda Devi

机构信息

Department of Pediatric Dentistry, Institute of Child Health and Research Hospital for Children, Egmore, Chennai, Tamil Nadu, India.

Department of Pediatric and Preventive Dentistry, Adiparasakthi Dental College and Hospital, Melmaruvathur, Chengalpattu, Tamil Nadu, India.

出版信息

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S774-S780. doi: 10.4103/jpbs.jpbs_168_22. Epub 2022 Jul 13.

Abstract

BACKGROUND

The goal for placement of intracanal medicament during pulpal therapy procedures is to eradicate the bacteria and the exotoxins from the infected root canal, thereby preventing and controlling pulpal and periradicular infections. Chemo-mechanical preparation is considered an essential step in root canal disinfection; but to accomplish the total elimination of bacteria in highly complex root canal anatomy is difficult. Intracanal medicaments help eliminate bacteria by remaining in the root canal, and calcium hydroxide has been recommended as one of the most effective antimicrobial dressings during endodontic therapy. The herbal agents offer an alternative to synthetic compounds. They have been considered either non-toxic or less toxic. The rapid increase in antibiotic-resistant strains and side effects caused by synthetic drugs have prompted researchers to look for herbal alternatives.

AIM AND OBJECTIVE

The study aims to evaluate and compare the antibacterial activity of triphala and calcium hydroxide against as an intracanal medicament.

MATERIALS AND METHODS

The antimicrobial efficacy of triphala and calcium hydroxide was evaluated against cultured and incubated for various time frames in 42 intact, caries-free, human, single-rooted teeth with straight roots and mature apices. The comparison of the number of counted colonies after each incubation time and based on the type of drug used inside the canal is evaluated using non-parametric Kruskal-Wallis test and Mann-Whitney test, respectively. Statistical analysis was done using SPSS version 14.0.

RESULTS

Efficacy of calcium hydroxide against was best in the first 72-hr time duration compared with triphala. Triphala showed significant antimicrobial activity against that was closely parallel to the calcium hydroxide group in one week. Calcium hydroxide and triphala had complete eradication of in a given one-month time duration.

摘要

背景

牙髓治疗过程中根管内药物放置的目标是根除感染根管内的细菌和外毒素,从而预防和控制牙髓及根尖周感染。化学机械预备被认为是根管消毒的关键步骤;但要在高度复杂的根管解剖结构中完全清除细菌是困难的。根管内药物通过留在根管内有助于清除细菌,氢氧化钙已被推荐为牙髓治疗中最有效的抗菌敷料之一。草药制剂为合成化合物提供了替代选择。它们被认为无毒或毒性较小。抗生素耐药菌株的迅速增加以及合成药物引起的副作用促使研究人员寻找草药替代品。

目的

本研究旨在评估和比较三果木和氢氧化钙作为根管内药物的抗菌活性。

材料与方法

在42颗完整、无龋、人单根直根且根尖成熟的牙齿中,评估三果木和氢氧化钙对培养并在不同时间框架内孵育的[具体细菌名称未给出]的抗菌效果。分别使用非参数Kruskal-Wallis检验和Mann-Whitney检验,根据根管内使用的药物类型,对每次孵育时间后计数的菌落数量进行比较。使用SPSS 14.0版本进行统计分析。

结果

与三果木相比,氢氧化钙在最初72小时内对[具体细菌名称未给出]的效果最佳。三果木对[具体细菌名称未给出]显示出显著的抗菌活性,在一周内与氢氧化钙组相近。在给定的一个月时间内,氢氧化钙和三果木都能完全根除[具体细菌名称未给出]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0d/9469354/7ea082d7837f/JPBS-14-774-g001.jpg

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