Qamar Seema, Jayanna Rashmi, Ahuja Vipin R
Department of Pediatric and Preventive Dentistry, Hazaribag College of Dental Sciences & Hospital, Hazaribagh, Jharkhand, India.
Department of Pediatric and Preventive Dentistry, Government Dental College and Hospital, Jamnagar, Gujarat, India.
Int J Clin Pediatr Dent. 2023 May-Jun;16(3):448-452. doi: 10.5005/jp-journals-10005-2599.
To compare and evaluate the antimicrobial efficacy against between a mix of calcium hydroxide [Ca(OH)] powder and normal saline, a mix of Ca(OH) powder and 2% chlorhexidine (CHX) gluconate solution, a mix of triple antibiotic powder (TAP) and normal saline, and mix of TAP and 2% CHX gluconate solution.
A total of 60 teeth were included in the study. The first sample (S1) was collected after access opening from the widest canal of the tooth by inserting sterile absorbable paper point no 20 up to the full length of the canal for 1 minute. The second sample (S2) was collected after the chemomechanical preparation and irrigation. After that, subjects were randomly divided into four groups-group I-a mix of Ca(OH) and normal saline; group II-a mix of Ca(OH) and 2% CHX; group III-a mix of TAP and normal saline; and group IV-a mix of TAP and 2% CHX. Assigned intracanal medicaments were placed in the canals, and the teeth were temporarily sealed with a temporary restorative material. On the 7th day, canals were reopened and irrigated, and a third bacteriological sample (S3) was taken out. Later, canals were filled with suitable obturating material, followed by the placement of the permanent restoration.
There was a very highly significant ( < 0.005) difference in count in all the groups on day 7 after placement of intracanal medicament, being highest in group IV followed by group II, group III, and group I.
Triple antibiotic powder (TAP) mixed with 2% CHX gluconate solution has superior antimicrobial efficacy against in primary teeth.
Qamar S, Jayanna R, Ahuja VR. Comparative Evaluation of Antimicrobial Efficacy of Calcium Hydroxide, Chlorhexidine, and Triple Antibiotic Paste in Different Combination Forms as Intracanal Medicaments against in Primary Teeth: An Randomized Clinical Trial. Int J Clin Pediatr Dent 2023;16(3):448-452.
比较并评估氢氧化钙[Ca(OH)]粉末与生理盐水的混合物、Ca(OH)粉末与2%葡萄糖酸氯己定（CHX）溶液的混合物、三联抗生素粉末（TAP）与生理盐水的混合物以及TAP与2% CHX葡萄糖酸溶液的混合物对[具体细菌名称未给出]的抗菌效果。
本研究共纳入60颗牙齿。第一个样本（S1）是在开髓后，通过将20号无菌可吸收纸尖插入牙齿最宽根管全长1分钟后采集。第二个样本（S2）是在化学机械预备和冲洗后采集。之后，受试者被随机分为四组——第一组：Ca(OH)与生理盐水的混合物；第二组：Ca(OH)与2% CHX的混合物；第三组：TAP与生理盐水的混合物；第四组：TAP与2% CHX的混合物。将指定的根管内药物置于根管中，并用临时修复材料暂时封闭牙齿。在第7天，重新打开根管并冲洗，取出第三个细菌学样本（S3）。之后，用合适的充填材料充填根管，随后进行永久修复。
在根管内药物放置后第7天，所有组的[细菌计数相关指标未明确给出]计数存在非常高度显著（<0.005）差异，第四组最高，其次是第二组、第三组和第一组。
三联抗生素粉末（TAP）与2% CHX葡萄糖酸溶液混合对乳牙中的[具体细菌名称未给出]具有卓越的抗菌效果。
Qamar S, Jayanna R, Ahuja VR. 不同组合形式的氢氧化钙、氯己定和三联抗生素糊剂作为根管内药物对乳牙中[具体细菌名称未给出]的抗菌效果比较评估：一项[具体研究类型未明确]随机临床试验。《国际临床儿科学牙科学杂志》2023；16(3):448 - 452。
