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不同分组的 IIIC 期乳腺癌患者死亡的非治疗性风险因素：美国监测、流行病学和最终结果数据库的研究。

Nontherapeutic Risk Factors of Different Grouped Stage IIIC Breast Cancer Patients' Mortality: A Study of the US Surveillance, Epidemiology, and End Results Database.

机构信息

Chinese PLA Medical School, Beijing 100853, China.

Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

出版信息

Breast J. 2022 Aug 30;2022:6705052. doi: 10.1155/2022/6705052. eCollection 2022.

DOI:10.1155/2022/6705052
PMID:36111212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9448578/
Abstract

OBJECTIVES: Stage IIIC breast cancer, as a local advanced breast cancer, has a poor prognosis compared with that of early breast cancer. We further investigated the risk factors of mortality in stage IIIC primary breast cancer patients and their predictive value. METHODS: We extracted data from the US Surveillance, Epidemiology, and End Results (SEER) database of female patients with stage IIIC primary breast cancer ( = 1673) from January 2011 to December 2015. RESULTS: Hormone receptor negativity ( ≤ 0.001 and ≤ 0.001, respectively), aggressive molecular typing ( ≤ 0.001 and ≤ 0.001, respectively), high stage ( ≤ 0.001 and ≤ 0.001, respectively), a high number of positive lymph nodes (≥14) (=0.005 and =0.001, respectively), and lymph node ratio (≥0.8148) ( ≤ 0.001 and ≤ 0.001, respectively) were associated with poor disease-specific survival. The indicators of disease-specific survival included estrogen receptor status, progesterone receptor status, molecular typing, stage, number of positive lymph nodes, and lymph node ratio ( ≤ 0.001, ≤ 0.001, ≤ 0.001, ≤ 0.001, =0.002, and ≤ 0.001, respectively). CONCLUSION: Hormone receptor negativity, aggressive molecular typing, high stage, high number of positive lymph nodes, and lymph node ratio are poor prognostic factors patients with stage IIIC primary breast cancer. The efficient indicators of disease-specific survival include estrogen receptor status, progesterone receptor status, molecular typing, stage, number of positive lymph nodes, and lymph node ratio.

摘要

目的：与早期乳腺癌相比，ⅡIC 期乳腺癌作为局部晚期乳腺癌，预后较差。我们进一步探讨了ⅡIC 期原发性乳腺癌患者死亡的危险因素及其预测价值。

方法：我们从 2011 年 1 月至 2015 年 12 月从美国监测、流行病学和最终结果（SEER）数据库中提取了女性ⅡIC 期原发性乳腺癌患者的数据（n=1673）。

结果：激素受体阴性（分别为≤0.001 和≤0.001）、侵袭性分子分型（分别为≤0.001 和≤0.001）、高分期（分别为≤0.001 和≤0.001）、阳性淋巴结数量较多（≥14）（=0.005 和=0.001）和淋巴结比值（≥0.8148）（分别为≤0.001 和≤0.001）与疾病特异性生存不良相关。疾病特异性生存的指标包括雌激素受体状态、孕激素受体状态、分子分型、分期、阳性淋巴结数量和淋巴结比值（分别为≤0.001、≤0.001、≤0.001、≤0.001、=0.002 和≤0.001）。

结论：激素受体阴性、侵袭性分子分型、高分期、阳性淋巴结数量较多和淋巴结比值是ⅡIC 期原发性乳腺癌患者的预后不良因素。疾病特异性生存的有效指标包括雌激素受体状态、孕激素受体状态、分子分型、分期、阳性淋巴结数量和淋巴结比值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/35459ec97903/TBJ2022-6705052.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/e6848dcff5ae/TBJ2022-6705052.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/a3dccd552674/TBJ2022-6705052.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/4df1935dac96/TBJ2022-6705052.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/35459ec97903/TBJ2022-6705052.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/e6848dcff5ae/TBJ2022-6705052.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/a3dccd552674/TBJ2022-6705052.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/4df1935dac96/TBJ2022-6705052.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f183/9448578/35459ec97903/TBJ2022-6705052.004.jpg

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本文引用的文献

[1]
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Zhonghua Zhong Liu Za Zhi. 2021-10-23

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Breast Cancer Res Treat. 2021-6

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Front Oncol. 2021-1-14

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Breast J. 2020-9

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Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer.

JAMA Netw Open. 2020-7-1

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