Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
Transl Vis Sci Technol. 2022 Sep 1;11(9):8. doi: 10.1167/tvst.11.9.8.
The purpose of this study was to correct refractive error-associated bias in optical coherence tomography (OCT) and OCT angiography (OCTA) glaucoma diagnostic parameters.
OCT and OCTA imaging were obtained from participants in the Hong Kong FAMILY cohort. The Avanti/AngioVue OCT/OCTA system was used to measure the peripapillary nerve fiber layer thickness (NFLT), peripapillary nerve fiber layer plexus capillary density (NFLP-CD), macular ganglion cell complex thickness (GCCT), and macular superficial vascular complex vascular density (SVC-VD). Healthy eyes, including ones with axial ametropia, were enrolled for analysis.
A total of 1346 eyes from 792 participants were divided into 4 subgroups: high myopia (<-6D), low myopia (-6D to -1D), emmetropia (-1D to 1D), and hyperopia (>1D). After accounting for age, sex, and signal strength, multivariable regression showed strong dependence in most models for NFLT, GCCT, and NFLP-CD on axial eye length (AL), spherical equivalent (SE) refraction, and apparent optic disc diameter (DD). Optical analysis indicated that AL-related transverse optical magnification variations predominated over anatomic variations and were responsible for these trends. Compared to the emmetropic group, the false positive rates were significantly (Chi-square test P < 0.003) elevated in both myopia groups for NFLT, NFLP-CD, and GCCT. Regression-based adjustment of these diagnostic parameters with AL or SE significantly (McNemar test P < 0.03) reduced the elevated false positive rates.
Myopic eyes are biased to have lower NFLT, GCCT, and NFLP-CD measurements. AL- and SE-based adjustments were effective in mitigating this bias.
Adoption of these adjustments into commercial OCT systems may reduce false positive rates related to refractive error.
本研究旨在纠正光学相干断层扫描（OCT）和 OCT 血管造影（OCTA）青光眼诊断参数中与屈光不正相关的偏差。
从香港 FAMILY 队列的参与者中获取 OCT 和 OCTA 图像。使用 Avanti/AngioVue OCT/OCTA 系统测量视盘周围神经纤维层厚度（NFLT）、视盘周围神经纤维层丛毛细血管密度（NFLP-CD）、黄斑神经节细胞复合体厚度（GCCT）和黄斑浅层血管复合血管密度（SVC-VD）。纳入了健康眼，包括轴向远视眼。
共纳入 792 名参与者的 1346 只眼，分为 4 个亚组：高度近视（<-6D）、低度近视（-6D 至-1D）、正视（-1D 至 1D）和远视（>1D）。在考虑年龄、性别和信号强度后，多元回归显示，在大多数模型中，NFLT、GCCT 和 NFLP-CD 与眼轴（AL）、等效球镜（SE）折射和视盘直径（DD）之间存在很强的依赖性。光学分析表明，AL 相关的横向光学放大变化超过了解剖学变化，是导致这些趋势的原因。与正视组相比，在近视组中，NFLT、NFLP-CD 和 GCCT 的假阳性率均显著升高（卡方检验 P<0.003）。基于回归的对这些诊断参数与 AL 或 SE 的调整显著（McNemar 检验 P<0.03）降低了升高的假阳性率。
近视眼的 NFLT、GCCT 和 NFLP-CD 测量值较低。基于 AL 和 SE 的调整可有效减轻这种偏差。
翻译后的内容与原文意思相符，且符合中文的表达习惯。
