Brockmueller Aranka, Mahmoudi Negin, Movaeni Amir Kian, Mueller Anna-Lena, Kajbafzadeh Abdol-Mohammad, Shakibaei Mehdi, Zolbin Masoumeh Majidi
Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-University Munich, Pettenkoferstrasse 11, 80336, Munich, Germany.
Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Neurochem Res. 2023 Jan;48(1):39-53. doi: 10.1007/s11064-022-03746-2. Epub 2022 Sep 16.
Neurodegenerative diseases refer to a group of neurological disorders as a consequence of various destructive illnesses, that predominantly impact neurons in the central nervous system, resulting in impairments in certain brain functions. Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and other neurodegenerative disorders represent a major risk to human health. In order to optimize structural and functional recovery, reconstructive methods integrate many approaches now, to address the complex and multivariate pathophysiology of neurodegenerative disorders. Stem cells, with their unique property of regeneration, offer new possibilities in regenerative and reconstructive medicine. Concurrently, there is an important role for natural products in controlling many health sufferings and they can delay or even prevent the onset of various diseases. In addition, due to their therapeutic properties, they have been used as neuroprotective agents to treat neurodegenerative disorders. After decades of intensive research, scientists made advances in treating these disorders so far, but current therapies are still not capable of preventing the illnesses from progressing. Therefore, in this review, we focused on a new perspective combining stem cells and natural products as an innovative therapy option in the management of neurodegenerative diseases.
神经退行性疾病是指由于各种破坏性疾病导致的一组神经系统疾病，这些疾病主要影响中枢神经系统中的神经元，导致某些脑功能受损。阿尔茨海默病、帕金森病、亨廷顿舞蹈症、多发性硬化症和其他神经退行性疾病对人类健康构成重大风险。为了优化结构和功能恢复，重建方法现在整合了多种方法，以应对神经退行性疾病复杂且多因素的病理生理学。干细胞具有独特的再生特性，为再生医学和重建医学提供了新的可能性。同时，天然产物在控制许多健康问题方面发挥着重要作用，它们可以延缓甚至预防各种疾病的发生。此外，由于其治疗特性，它们已被用作神经保护剂来治疗神经退行性疾病。经过数十年的深入研究，科学家们到目前为止在治疗这些疾病方面取得了进展，但目前的疗法仍然无法阻止疾病的进展。因此，在本综述中，我们重点关注将干细胞和天然产物相结合的新视角，作为神经退行性疾病管理中的一种创新治疗选择。
