内体循环缺陷将亨廷顿病与 McLeod 综合征联系起来。
Endosomal recycling defects link Huntington's disease with McLeod syndrome.
机构信息
Department of Pathology, University of California, San Francisco, San Francisco, CA.
Pathology Service 113B, San Francisco Veterans Administrations Health Care System, San Francisco, CA.
出版信息
J Cell Biol. 2022 Oct 3;221(10). doi: 10.1083/jcb.202208164. Epub 2022 Sep 16.
Abstract
Chhetri and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.
摘要
切特里等人（2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073）表明 Rab11 介导的内体再循环调节 McLeod 综合征蛋白 XK 的细胞表面表达。突变型亨廷顿蛋白干扰 XK 的再循环到细胞表面，并显著降低跨细胞膜的锰运输。
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