Health Sciences University, Kanuni Sultan Suleyman Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey. .
Istanbul Atlas University, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey.
J Gastrointestin Liver Dis. 2022 Sep 15;31(3):309-316. doi: 10.15403/jgld-4390.
We aimed to evaluate the circulating thrombospondin-1 (TSP-1) and nuclear factor kappa B (NF-κB) in nonalcoholic fatty liver disease (NAFLD) in order to integrate these signaling pathways in the inflammatory and fibrogenic processes of this liver disorder.
Ninety-five NAFLD patients were recruited in the study. The study also included 83 age-sex matched healthy controls.
The number of patients with metabolic syndrome (MetS) criteria was 57 (60%). TSP-1 level was found to be statistically significantly lower in the NAFLD group compared to the control group (p=0.037). However, NF-κB level was found to be significantly higher in the NAFLD group compared to the control group (p=0.004). There was a significant negative correlation between plasma TSP-1 levels with glucose (r=-0.235, p=0.022), alanine aminotransferase (r=-0.261, p=0.011) and aspartate transaminase (r=-0.328, p=0.001) levels. In addition, a significant negative correlation was found between plasma TSP-1 and NF-κB levels (r=-0.729, p<0.001).
Our results suggest a close relationship between increased NF-κB and reduced TSP-1 in NAFLD. TSP-1 and NF-κB signaling pathways might have a role in the inflammatory and fibrogenic processes. Furthermore, they may be used as a noninvasive marker and could assist as a therapeutic target for NAFLD.
评估非酒精性脂肪性肝病（NAFLD）患者循环中血小板反应蛋白-1（TSP-1）和核因子-κB（NF-κB）的水平，以整合这些信号通路在该肝病的炎症和纤维化过程中的作用。
研究共纳入 95 例 NAFLD 患者，并纳入 83 例年龄和性别相匹配的健康对照者。
符合代谢综合征（MetS）标准的患者有 57 例（60%）。与对照组相比，NAFLD 组患者的 TSP-1 水平显著降低（p=0.037）。然而，NAFLD 组患者的 NF-κB 水平显著高于对照组（p=0.004）。血浆 TSP-1 水平与血糖（r=-0.235，p=0.022）、丙氨酸转氨酶（r=-0.261，p=0.011）和天门冬氨酸转氨酶（r=-0.328，p=0.001）水平呈显著负相关。此外，还发现血浆 TSP-1 与 NF-κB 水平呈显著负相关（r=-0.729，p<0.001）。
我们的研究结果提示 NF-κB 增加和 TSP-1 减少之间在 NAFLD 中存在密切关系。TSP-1 和 NF-κB 信号通路可能在炎症和纤维化过程中起作用。此外，它们可能作为非侵入性标志物，有助于成为 NAFLD 的治疗靶点。
