Richards J A, Cole D A, Hickey R J, Sokol L S
J Chromatogr Sci. 1987 Jul;25(7):292-5. doi: 10.1093/chromsci/25.7.292.
A high performance liquid chromatographic assay for piroxicam in pharmaceutical preparations is described. The method uses a reversed-phase C18 column with pH 3 aqueous buffer/methanol, 55:45, v/v mobile phase, and is selective for piroxicam in the presence of other "oxicams," synthetic precursors, by-products, degradation products, metabolites, and related compounds. Applications to capsules, tablets, ointments, suppositories, ophthalmic suspensions, and rodent feeds are cited.
