Wilkes M K, McKerrell R E, Patterson R C, Palmer A C
J Comp Pathol. 1987 May;97(3):247-56. doi: 10.1016/0021-9975(87)90088-0.
Morphometric analysis was carried out on electron micrographs of motor endplates from three Jack Russell terriers affected with congenital myasthenia gravis (CMG) aged 10 weeks, 12 weeks and 22 weeks, respectively. Control endplates from age-matched pups and an adult Jack Russell were also examined. The results showed that postsynaptic membrane density was significantly increased in affected animals and secondary fold length was decreased. The ratio of postsynaptic to presynaptic membrane length was normal in the 10 and 12-week-old pups, but reduced in the 22-week-old CMG animal. These changes were unrelated to muscle fibre diameter and there was no evidence of a destructive process. It is suggested that the alteration in membrane folding pattern in this condition may be related to abnormal trophic influences during synaptogenesis.
对三只分别为10周龄、12周龄和22周龄的患有先天性重症肌无力（CMG）的杰克罗素梗犬运动终板的电子显微照片进行了形态计量分析。还检查了来自年龄匹配幼犬和成年杰克罗素梗犬的对照终板。结果表明，患病动物的突触后膜密度显著增加，次级褶皱长度减少。10周龄和12周龄幼犬的突触后与突触前膜长度之比正常，但22周龄的CMG动物该比例降低。这些变化与肌纤维直径无关，也没有破坏过程的证据。提示在这种情况下膜折叠模式的改变可能与突触发生过程中异常的营养影响有关。
