Tsujihata M, Hazama R, Ishii N, Ide Y, Mori M, Takamori M
Neurology. 1979 May;29(5):654-61. doi: 10.1212/wnl.29.5.654.
Motor endplate ultrastructure in the biceps brachii was quantitatively analyzed in five patients with ocular myasthenia gravis (56 endplates), six patients with generalized myasthenia gravis (83 endplates), and five controls (64 endplates). Ultrastructural changes of the motor endplates were observed in nonweak limb muscles of patients with ocular myasthenia gravis as well as in generalized myasthenia; these changes were mostly restricted to the postsynaptic region. Decrease of the mean presynaptic and postsynaptic membrane length, and postsynaptic membrane density, were more remarkable in generalized myasthenia than in ocular myasthenia. Widening of the primary and secondary synaptic clefts was also observed more frequently in generalized myasthenia. There was no correlation between ultrastructural alterations and the duration of symptoms or treatment, severity of disease, or titers of antiacetylcholine receptor antibody.
对5例眼肌型重症肌无力患者（56个终板）、6例全身型重症肌无力患者（83个终板）和5例对照者（64个终板）的肱二头肌运动终板超微结构进行了定量分析。在眼肌型重症肌无力患者以及全身型重症肌无力患者的非无力肢体肌肉中均观察到运动终板的超微结构变化；这些变化大多局限于突触后区域。全身型重症肌无力患者突触前和突触后膜平均长度以及突触后膜密度的降低比眼肌型重症肌无力患者更显著。全身型重症肌无力患者中还更频繁地观察到初级和次级突触间隙增宽。超微结构改变与症状持续时间或治疗、疾病严重程度或抗乙酰胆碱受体抗体滴度之间无相关性。
