麻醉剂对大鼠脑和骨骼肌中磷酸肌酸、三磷酸腺苷及乳酸浓度的影响。

The effect of anaesthetics on the concentration of creatine phosphate, adenosine triphosphate and lactate in brain and skeletal muscle of the rat.

作者信息

McLoughlin J V, Wheatley A M, Wilson P

出版信息

J Comp Pathol. 1987 May;97(3):341-9. doi: 10.1016/0021-9975(87)90099-5.

Abstract

Rats were anaesthetized with ten anaesthetics. Ketamine and enflurane gave the lowest concentration of creatine phosphate and ATP and the highest of lactate in brain, while giving the highest concentration of the high-energy phosphates and the lowest of lactate in skeletal muscle. In general, intraperitoneally-administered anaesthetics gave higher concentrations of creatine phosphate and ATP and lower concentrations of lactate in brain than did the inhalant anaesthetics. The most rapid induction of anaesthesia was achieved with halothane and enflurane, while ketamine gave variable induction times and poor analgesia. Halothane stimulated glycolysis and lowered the concentrations of high-energy phosphates in skeletal muscle.

摘要

用十种麻醉剂对大鼠进行麻醉。氯胺酮和恩氟烷使脑中磷酸肌酸和三磷酸腺苷（ATP）的浓度最低，乳酸浓度最高，而使骨骼肌中高能磷酸盐的浓度最高，乳酸浓度最低。一般来说，与吸入性麻醉剂相比，腹腔注射麻醉剂使脑中磷酸肌酸和ATP的浓度更高，乳酸浓度更低。氟烷和恩氟烷实现了最快速的麻醉诱导，而氯胺酮的诱导时间不一且镇痛效果不佳。氟烷刺激糖酵解并降低骨骼肌中高能磷酸盐的浓度。