Biomaterials and Biotechnology Laboratory, Science and Technology Research and Application Center (BITAM), Necmettin Erbakan University, 42140 Konya, Turkey.
Biomaterials and Biotechnology Laboratory, Science and Technology Research and Application Center (BITAM), Necmettin Erbakan University, 42140 Konya, Turkey; Department of Chemistry Education, A.K. Education Faculty, Necmettin Erbakan University, 42090 Konya, Turkey.
J Pharm Biomed Anal. 2022 Nov 30;221:115031. doi: 10.1016/j.jpba.2022.115031. Epub 2022 Sep 7.
Advancements in nanoscience and nanotechnology have opened new pathways to fabricate novel nanostructures with interesting properties that would be used for different applications. In this respect, nanostructures comprising chirality are one of the most rapidly developing research fields encompassing chemistry, physics and biology. Chirality, also known as mirror asymmetry, describes the geometrical property of an object that is not superimposable on its mirror image. This characteristic plays a crucial role because these identical forms of chiral species in pharmaceuticals or food additives may exhibit different effects on living organisms. Therefore, chiral analysis is an important field of modern chemical analysis in health-related industries that are reliant on the production of enantiomeric compounds involving pharmaceuticals. This review covers the recent advances dealing with the synthesis, design and advantageous analytical performance of nanomaterials-enriched sensors used for chiral pharmaceuticals. We conclude this review with the challenges existing in this research field and our perspectives on some potential strategies with cutting-edge approaches for the rational design of sensors for chiral pharmaceuticals. We expect this comprehensive review will inspire future studies in nanomaterials-enriched chiral sensors.
纳米科学和纳米技术的进步为制造具有有趣性质的新型纳米结构开辟了新途径，这些纳米结构将用于不同的应用。在这方面，包含手性的纳米结构是化学、物理和生物学中发展最快的研究领域之一。手性，也称为镜像不对称，描述了一个物体的几何性质，它不能与其镜像重叠。这个特性起着至关重要的作用，因为在药物或食品添加剂中，这些手性物质的相同形式可能对生物体表现出不同的影响。因此，手性分析是与健康相关产业中现代化学分析的一个重要领域，这些产业依赖于涉及药物的对映异构体化合物的生产。本综述涵盖了用于手性药物的合成、设计和具有优势的分析性能的富含纳米材料的传感器的最新进展。我们在本文中总结了该研究领域存在的挑战，并对一些具有前沿方法的潜在策略进行了展望，以期对手性药物传感器进行合理设计。我们希望这篇综述能激发对手性纳米材料传感器的未来研究。
