Kumar B, Kaur S, Kaur I, Gangowar D N
Indian J Lepr. 1987 Jan-Mar;59(1):63-74.
Local and systemic side effects of clofazimine in 514 Leprosy and 26 vitiligo patients who had taken the drug in different doses (100 mg to 300 mg daily) for variable periods of time. The commonest side effect noted was reddish brown pigmentation of skin in 77.8% patients. In an equal number of patients, ichthyotic changes on the peripheral parts of the body were noticed. GIT symptoms occurred only in 0.04% patients in the form of abdominal pain, epigastric distress, mild transient nausea and anorexia. Other minor side effects noted were reddish coloration of sweat, urine and tears. Schilling's, d-xylose tests and faecal fat excretion were near normal in the 21 patients in whom these parameters were done. No abnormality in the Jejunal mucosal biopsy was observed after therapy. No abnormality in the EKG or serum biochemistry occurred even after prolonged therapy. We found the drug to be very safe in the usual doses.
514名麻风病患者和26名白癜风患者服用不同剂量（每日100毫克至300毫克）的氯法齐明达不同时长后的局部和全身副作用。最常见的副作用是77.8%的患者出现皮肤红棕色色素沉着。同样数量的患者身体外周部位出现鱼鳞病样改变。胃肠道症状仅在0.04%的患者中出现，表现为腹痛、上腹部不适、轻度短暂恶心和厌食。其他轻微副作用包括汗液、尿液和泪液发红。在进行这些参数检测的21名患者中，希林试验、d-木糖试验和粪便脂肪排泄接近正常。治疗后空肠黏膜活检未观察到异常。即使经过长期治疗，心电图或血清生化指标也未出现异常。我们发现该药物在常用剂量下非常安全。
