在一名曾接受胃旁路手术的患者发生严重文拉法辛过量中毒的情况下给予脂肪乳剂治疗。
Intralipid administration in case of a severe venlafaxine overdose in a patient with previous gastric bypass surgery.
作者信息
de Wit D, Franssen E J F, Verstoep N
机构信息
Department of Clinical Pharmacy, BovenIJ hospital, Amsterdam, the Netherlands.
Department of Clinical Pharmacy, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
出版信息
Toxicol Rep. 2022 May 17;9:1139-1141. doi: 10.1016/j.toxrep.2022.05.008. eCollection 2022.
This case describes a patient with a history of bariatric surgery who was admitted to our hospital with a severe venlafaxine intoxication. Due to the altered anatomy of the gastrointestinal tract, the use of oral activated charcoal and large volumes of laxatives to prevent further uptake of venlafaxine was hampered. This resulted in massive absorption and a severe serotonergic syndrome. The patient was successfully treated with intravenous lipid emulsion.
本病例描述了一名有减肥手术史的患者，因严重的文拉法辛中毒入住我院。由于胃肠道解剖结构改变，口服活性炭和大量泻药以防止文拉法辛进一步吸收受到阻碍。这导致大量吸收并引发严重的血清素能综合征。该患者通过静脉输注脂质乳剂成功治愈。
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