Bosse George M, Spiller Henry A, Collins Aaron M
Department of Emergency Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
J Med Toxicol. 2008 Mar;4(1):18-20. doi: 10.1007/BF03160945.
Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects.
A 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed significant QRS and QTC interval prolongation prior to his demise.
A literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.
基于其对5-羟色胺再摄取的抑制作用，预计过量服用文拉法辛会产生5-羟色胺能效应。
一名40岁男性在自杀未遂时单独服用了文拉法辛，未同时摄入其他物质。患者出现难治性心室颤动，摄入后约9小时死亡。心电图监测显示，在其死亡前QRS和QTC间期显著延长。
对文拉法辛过量病例进行了文献综述，并对其作用机制进行了研究。讨论了钠通道阻滞的可能性及其对治疗的影响。
