Ayisire Oghenetega E, Okobi Okelue E, Adaralegbe Ngozi J, Adeosun Adeyemi A, Sood Divyaanshi, Onyechi Nkemputaife P, Agazie Ogochukwu, Shittu Hameed O, Akinsola Zainab, Nnaji Chukwudike G, Owolabi Oluwasayo J, Umeh Nneka J, Imobighe Imolikhe C, Adedoyin Adewale M, Usman Madinah
Psychiatry, University of South Wales, Pontypridd, GBR.
Family Medicine, Lakeside Medical Center, Belle Glade, USA.
Cureus. 2022 Aug 12;14(8):e27926. doi: 10.7759/cureus.27926. eCollection 2022 Aug.
Cannabis use and depression management have been studied, with a preponderance of exacerbating effects, but there are few studies on postpartum depression (PPD). Depression affects a significant number of women, with a portion of it manifesting as PPD in childbearing women in the United States each year. The pharmacologic management approaches have disadvantages such as side effects, cost-benefit ratio, contraindications, use reluctance, medication adherence, and stigmatization in patients. Anecdotal claims of medical cannabis' therapeutic benefits have led to widespread legalization in several regions, making cannabis and its extracts a possible alternative. Cannabis is widely used during pregnancy and in general. Even though substance use disorders exacerbating depression symptoms have been reported, there are increasing reports and evidence about the therapeutic benefit of dose-dependent cannabis or its extracts in some depression symptoms, such as acute psychosocial stress relief, its purported anxiolytic effect, appetite, and sleep quality, thus stimulating more interest that may be inferred to depression. PPD marijuana use is unclear. This paper reviewed works of literature that claimed cannabis' therapeutic benefit in treating depression and, by extension, PPD. Our findings show the link between cannabis and PPD has not been fully explored. Self-reported studies link marijuana uses to positive mood, anxiety relief, sleep regulation, nausea and vomiting reduction, and appetite stimulation-all PPD symptoms. Others opposed postpartum marijuana use.
大麻使用与抑郁症治疗的关系已得到研究，多数研究表明大麻会产生加剧作用，但关于产后抑郁症（PPD）的研究较少。抑郁症影响着大量女性，在美国，每年有一部分女性在生育期会出现产后抑郁症。药物治疗方法存在诸多弊端，如副作用、成本效益比、禁忌症、患者不愿使用、药物依从性以及污名化等问题。一些关于医用大麻治疗益处的传闻促使其在多个地区广泛合法化，使得大麻及其提取物成为一种可能的替代选择。大麻在孕期及总体上被广泛使用。尽管有报道称物质使用障碍会加剧抑郁症状，但越来越多的报道和证据表明，剂量依赖性的大麻或其提取物在某些抑郁症状方面具有治疗益处，如缓解急性心理社会压力、其所谓的抗焦虑作用、食欲和睡眠质量，从而引发了更多可能与抑郁症相关的兴趣。产后使用大麻治疗抑郁症的情况尚不清楚。本文回顾了一些声称大麻在治疗抑郁症及由此延伸至产后抑郁症方面具有治疗益处的文献。我们的研究结果表明，大麻与产后抑郁症之间的联系尚未得到充分探讨。自我报告研究将大麻使用与积极情绪、缓解焦虑、调节睡眠、减少恶心和呕吐以及刺激食欲——所有这些都是产后抑郁症的症状联系起来。其他人则反对产后使用大麻。
