内皮细胞激活和应激指数（EASIX）作为小细胞肺癌的预测生物标志物。
Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer.
机构信息
Division of Hematology-Oncology, Department of Internal Medicine, Institute of Health Science, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea.
Division of Hematology-Oncology, Department of Internal Medicine, Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.
出版信息
Cancer Biomark. 2022;35(2):217-225. doi: 10.3233/CBM-220032.
BACKGROUND
Endothelial activation and insult may contribute to the aggressive clinical course of small-cell lung cancer (SCLC); however, no predictive biomarker for this pathogenesis has been identified.
OBJECTIVE
To evaluate the clinical impact of the endothelial activation and stress index (EASIX) in SCLC.
METHODS
In this retrospective study, the EASIX was calculated from measurements of serum lactate dehydrogenase, creatinine, and platelet levels. A total of 264 patients with SCLC treated with platinum-based chemotherapy were stratified into high and low EASIX groups.
RESULTS
Complete and objective response rates in the limited-stage (LD) were 19.5% vs. 33.3% (P= 0.050) and 85.4% vs. 97.9% (P= 0.028) in the high and low EASIX groups, respectively. There was no significant difference in the response rate between the two groups in the extensive-stage (ED). The median overall survival was 9.8 vs. 40.5 months in LD (P< 0.001) and 7.2 vs. 11.9 months in ED (P< 0.001) in the high and low EASIX groups, respectively. In multivariate analyses, a high EASIX level was an independent prognostic factor for worse progression-free and overall survival irrespective of stage.
CONCLUSION
EASIX may be a potential predictive biomarker of SCLC.
背景
内皮细胞激活和损伤可能导致小细胞肺癌（SCLC）的侵袭性临床病程；然而，尚未确定这种发病机制的预测性生物标志物。
目的
评估内皮细胞激活和应激指数（EASIX）在 SCLC 中的临床影响。
方法
在这项回顾性研究中，EASIX 是通过测量血清乳酸脱氢酶、肌酐和血小板水平计算得出的。将 264 名接受铂类化疗治疗的 SCLC 患者分为高和低 EASIX 组。
结果
局限期（LD）的完全缓解率和客观缓解率分别为 19.5%和 33.3%（P=0.050）以及 85.4%和 97.9%（P=0.028），在高和低 EASIX 组之间。两组在广泛期（ED）的缓解率无显著差异。在 LD 中，高 EASIX 组的中位总生存期为 9.8 个月 vs. 40.5 个月（P<0.001），在 ED 中，高 EASIX 组的中位总生存期为 7.2 个月 vs. 11.9 个月（P<0.001）。在多变量分析中，高 EASIX 水平是无不论分期的无进展生存期和总生存期较差的独立预后因素。
结论
EASIX 可能是 SCLC 的一个潜在预测性生物标志物。
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