Phillips T W, Johnston G, Wood P
J Arthroplasty. 1987;2(2):111-7. doi: 10.1016/s0883-5403(87)80017-7.
This study was done to determine whether sheep provide a better model of resurfacing hip arthroplasty than dogs. Eighteen sheep were subjected to unilateral resurfacing arthroplasty. Fifty-eight percent developed femoral loosening by 10 months. This reflects the clinical situation in humans: loosening has been the leading cause of failure. By contrast, reports of experiments with dogs describe very low loosening rates. Sheep provide a more stringent test of hip arthroplasty than dogs. The critical difference appears to be activity level. Sheep allowed free activity on a farm more closely simulate the situation of active patients than do dogs housed in small enclosures in conventional research facilities. New techniques of prosthetic hip arthroplasty that lend themselves to animal models should be studied in sheep before being studied in humans.
本研究旨在确定绵羊是否比犬类更适合作为髋关节表面置换术的模型。18只绵羊接受了单侧表面置换关节成形术。到10个月时，58%的绵羊出现了股骨松动。这反映了人类的临床情况：松动一直是失败的主要原因。相比之下，有关犬类实验的报告显示松动率非常低。与犬类相比，绵羊对髋关节置换术的测试更为严格。关键差异似乎在于活动水平。与饲养在传统研究设施小围栏中的犬类相比，在农场自由活动的绵羊更接近活跃患者的情况。适用于动物模型的新型人工髋关节置换技术，在应用于人体研究之前，应先在绵羊身上进行研究。
