Department of Plastic Surgery, The First Hospital of China Medical University, 110001 Shenyang, Liaoning Province, PR China.
Department of Plastic Surgery, The First Hospital of China Medical University, 110001 Shenyang, Liaoning Province, PR China; Liaoning Provincial Key Laboratory of Oral Diseases, School of Stomatology and Department of Oral Pathology, School of Stomatology, China Medical University, 110001 Shenyang, Liaoning Province, PR China.
J Control Release. 2022 Nov;351:407-431. doi: 10.1016/j.jconrel.2022.09.023. Epub 2022 Sep 27.
Oral solid dosage form is currently the most common used form of drug. 3D Printing, also known as additive manufacturing (AM), can quickly print customized and individualized oral solid dosage form on demand. Compared with the traditional tablet manufacturing process, 3D Printing has many advantages. By rationally selecting the formulation composition and cleverly designing the printing structure, 3D printing can improve the solubility of the drug and achieve precise modify of the drug release. 3D printed oral solid dosage form, however, still has problems such as limitations in formulation selection. And the selection process of the formulation lacks scientificity and standardization. Structural design of some 3D printing approaches is relatively scarce. This article reviews the formulation selection and structure design of 3D printed oral solid dosage form, providing more ideas for achieving modified drug release and solubility improvement of 3D printed oral solid dosage form through more scientific and extensive formulation selection and more sophisticated structural design.
口服固体制剂是目前最常用的药物剂型。3D 打印，又称增材制造（AM），可以按需快速打印定制化和个体化的口服固体制剂。与传统的片剂制造工艺相比，3D 打印具有许多优势。通过合理选择配方组成和巧妙设计打印结构，可以提高药物的溶解度，并实现药物释放的精确调控。然而，3D 打印的口服固体制剂仍然存在一些问题，如在配方选择方面存在局限性，而且配方选择过程缺乏科学性和标准化。一些 3D 打印方法的结构设计相对较少。本文综述了 3D 打印口服固体制剂的配方选择和结构设计，通过更科学、更广泛的配方选择和更复杂的结构设计，为实现 3D 打印口服固体制剂的药物释放改性和溶解度提高提供了更多思路。
