Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratório de Nanocarreadores e Impressão 3D em Tecnologia Farmacêutica (Nano3D), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Int J Pharm. 2022 Sep 25;625:122066. doi: 10.1016/j.ijpharm.2022.122066. Epub 2022 Aug 1.
Three-dimensional (3D) printing has been gaining attention as a new technological approach to obtain immediate release (IR) dosage forms. The versatility conferred by 3D printing techniques arises from the suitability of using different polymeric materials in the production of solids with different porosities, geometries, sizes, and infill patterns. The appropriate choice of polymer can facilitate in reaching IR specifications and afford other specific properties to 3D printed solid dosage forms. This review aims to provide an overview of the polymers that have been employed in the development of IR 3D printed dosage forms, mainly considering their in vitro drug release behaviour. The physicochemical and mechanical properties of the IR 3D printed dosage forms will also be discussed, together with the manufacturing process strategies. Up to now, methacrylic polymers, cellulosic polymers, vinyl derivatives, glycols and different polymeric blends have been explored to produce IR 3D printed dosage forms. Their effects on drug release profiles are critically discussed here, giving a complete overview to drive formulators towards a rational choice of polymeric material and thus contributing to future studies in 3D printing of pharmaceuticals.
三维（3D）打印作为一种获得即时释放（IR）剂型的新技术方法，受到了越来越多的关注。3D 打印技术的多功能性源于其适用于生产具有不同孔隙率、几何形状、尺寸和填充模式的固体的不同聚合物材料。聚合物的适当选择可以促进达到 IR 规格，并为 3D 打印的固体剂型提供其他特定性能。本综述旨在概述用于开发 IR 3D 打印剂型的聚合物，主要考虑其体外药物释放行为。IR 3D 打印剂型的物理化学和机械性能也将与制造工艺策略一起进行讨论。到目前为止，已经探索了甲基丙烯酸聚合物、纤维素聚合物、乙烯基衍生物、二醇和不同聚合物共混物来生产 IR 3D 打印剂型。本文批判性地讨论了它们对药物释放曲线的影响，为制剂师提供了全面的选择聚合物材料的概述，从而为未来的制药 3D 打印研究做出贡献。
